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In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications
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In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications
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Journal Article
In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications
2017
Overview
Bioprinting has emerged as a novel technological approach with the potential to address unsolved questions in the field of tissue engineering. We have recently shown that Laser Assisted Bioprinting (LAB), due to its unprecedented cell printing resolution and precision, is an attractive tool for the
in situ
printing of a bone substitute. Here, we show that LAB can be used for the
in situ
printing of mesenchymal stromal cells, associated with collagen and nano-hydroxyapatite, in order to favor bone regeneration, in a calvaria defect model in mice. Also, by testing different cell printing geometries, we show that different cellular arrangements impact on bone tissue regeneration. This work opens new avenues on the development of novel strategies, using
in situ
bioprinting, for the building of tissues, from the ground up.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
