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Endothelial cell infection and endotheliitis in COVID-19
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Journal Article
Endothelial cell infection and endotheliitis in COVID-19
2020
Overview
The mechanisms underlying the disproportionate effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on patients with cardiovascular comorbidities, however, remain incompletely understood.1,2 SARS-CoV-2 infects the host using the angiotensin converting enzyme 2 (ACE2) receptor, which is expressed in several organs, including the lung, heart, kidney, and intestine. Intriguingly, SARS-CoV-2 can directly infect engineered human blood vessel organoids in vitro.4 Here we demonstrate endothelial cell involvement across vascular beds of different organs in a series of patients with COVID-19 (further case details are provided in the appendix). The vascular endothelium is an active paracrine, endocrine, and autocrine organ that is indispensable for the regulation of vascular tone and the maintenance of vascular homoeostasis.5 Endothelial dysfunction is a principal determinant of microvascular dysfunction by shifting the vascular equilibrium towards more vasoconstriction with subsequent organ ischaemia, inflammation with associated tissue oedema, and a pro-coagulant state.6 Our findings show the presence of viral elements within endothelial cells and an accumulation of inflammatory cells, with evidence of endothelial and inflammatory cell death.
Publisher
Elsevier Ltd,Elsevier Limited
Subject
/ Aged
/ Angiotensin-converting enzyme 2
/ Autopsy
/ Betacoronavirus - pathogenicity
/ Coronavirus Infections - immunology
/ Coronavirus Infections - pathology
/ COVID-19
/ Diabetes
/ Edema
/ Endothelial Cells - virology
/ Female
/ Humans
/ Ischemia
/ Kidney
/ Male
/ Organs
/ Patients
/ Pneumonia, Viral - immunology
/ Pneumonia, Viral - pathology
