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Serum Clara Cell Protein: A Sensitive Biomarker of Increased Lung Epithelium Permeability Caused by Ambient Ozone
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Serum Clara Cell Protein: A Sensitive Biomarker of Increased Lung Epithelium Permeability Caused by Ambient Ozone
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Journal Article
Serum Clara Cell Protein: A Sensitive Biomarker of Increased Lung Epithelium Permeability Caused by Ambient Ozone
2000
Overview
Ozone in ambient air may cause various effects on human health, including decreased lung function, asthma exacerbation, and even premature mortality. These effects have been evidenced using various clinical indicators that, although sensitive, do not specifically evaluate the O3-increased lung epithelium permeability. In the present study, we assessed the acute effects of ambient O3on the pulmonary epithelium by a new approach relying on the assay in serum of the lung-specific Clara cell protein (CC16 or CC10). We applied this test to cyclists who exercised for 2 hr during episodes of photochemical smog and found that O3induces an early leakage of lung Clara cell protein. The protein levels increased significantly into the serum from exposure levels as low as 0.060-0.084 ppm. Our findings, confirmed in mice exposed to the current U.S. National Ambient Air Quality Standards for O3(0.08 ppm for 8 hr) indicate that above the present natural background levels, there is almost no safety margin for the effects of ambient O3on airway permeability. The assay of CC16 in the serum represents a new sensitive noninvasive test allowing the detection of early effects of ambient O3on the lung epithelial barrier.
Publisher
National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare,National Institute of Environmental Health Sciences
