Asset Details
Do you wish to reserve the book?
Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model
Do you wish to request the book?
Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model
2021
Overview
Mild head trauma, including concussion, can lead to chronic brain dysfunction and degeneration but the underlying mechanisms remain poorly understood. Here, we developed a novel head impact system to investigate the long-term effects of mild head trauma on brain structure and function, as well as the underlying mechanisms in
Drosophila melanogaster
. We find that
Drosophila
subjected to repetitive head impacts develop long-term deficits, including impaired startle-induced climbing, progressive brain degeneration, and shortened lifespan, all of which are substantially exacerbated in female flies. Interestingly, head impacts elicit an elevation in neuronal activity and its acute suppression abrogates the detrimental effects in female flies. Together, our findings validate
Drosophila
as a suitable model system for investigating the long-term effects of mild head trauma, suggest an increased vulnerability to brain injury in female flies, and indicate that early altered neuronal excitability may be a key mechanism linking mild brain trauma to chronic degeneration.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
