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Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia
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Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia
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Journal Article
Cis P-tau is a central circulating and placental etiologic driver and therapeutic target of preeclampsia
2023
Overview
Preeclampsia (PE) is the leading cause of maternal and fetal mortality globally and may trigger dementia later in life in mothers and their offspring. However, the etiological drivers remain elusive.
Cis
P-tau is an early etiological driver and blood biomarker in pre-clinical Alzheimer’s and after vascular or traumatic brain injury, which can be targeted by stereo-specific antibody, with clinical trials ongoing. Here we find significant
cis
P-tau in the placenta and serum of PE patients, and in primary human trophoblasts exposed to hypoxia or sera from PE patients due to Pin1 inactivation. Depletion of
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P-tau from PE patient sera by the antibody prevents their ability to disrupt trophoblast invasion and endovascular activity and to cause the PE-like pathological and clinical features in pregnant humanized tau mice. Our studies uncover that
cis
P-tau is a central circulating etiological driver and its stereo-specific antibody is valuable for early PE diagnosis and treatment.
Preeclampsia is the leading cause of maternal and fetal mortality worldwide. Here, the authors show that
cis
P-tau is a central circulating etiologic driver in preeclampsia and that the stereo-specific antibody targeting
cis
P-tau holds promise for early diagnosis and treatment of the disease.
