Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

The DNA methylation landscape of advanced prostate cancer

by Li, Haolong , Huang, Jiaoti , Bose, Rohit , Boutros, Paul C. , Chesner, Lisa , Hua, Junjie T. , Moussavi-Baygi, Ruhollah , Alshalalfa, Mohammed , Beer, Tomasz M. , Feng, Felix Y. , Batzoglou, Serafim , Gleave, Martin , Alumkal, Joshi J. , Barnard, Travis J. , Evans, Christopher P. , Dang, Ha X. , Chi, Kim N. , Shenoy, Tanushree , Lara, Primo N. , He, Housheng H. , Febbo, Phillip , Asangani, Irfan A. , Sjöström, Martin , Chen, William S. , Liao, Arnold , Yvonne Kim, M. , Rettig, Matthew B. , Sandhu, Shahneen , Yang, Rendong , Laura Chang, S. , Zwart, Wilbert , Witte, Owen , Huang, Franklin W. , Small, Eric J. , Morgan, Todd M. , Chinnaiyan, Arul M. , Chow, Eric D. , Tomlins, Scott A. , Costello, Joseph F. , Das, Rajdeep , Zhang, Meng , Playdle, Denise , Dehm, Scott M. , Perry, Marc D. , Farh, Kyle , Lang, Joshua M. , Fong, Lawrence , Thomas, George , Luo, Jianhua , Reiter, Robert E. , Aggarwal, Rahul , Maher, Christopher A. , Mahajan, Nupam P. , Gilbert, Luke A. , Ashworth, Alan , Knudsen, Karen E. , Foye, Adam , Houlahan, Kathleen E. , Zhang, Li , Zoubeidi, Amina , Li, Hui , Wyatt, Alexander W. , Bailey, Adina M. , Quigley, David A. , Zhao, Shuang G. , Goodarzi, Hani , Spratt, Da

in 45/23 / 631/208/177 / 631/67/589/466 / Aged / Aged, 80 and over / Agriculture / Animal Genetics and Genomics / Binding sites / Biomedical and Life Sciences / Biomedicine / Biopsy / Bisulfite / Cancer / Cancer Research / Carcinogenesis - genetics / Castration / Deoxyribonucleic acid / Development and progression / DNA / DNA methylation / DNA Methylation - genetics / Epigenetics / Epigenomics - methods / Gene expression / Gene Expression Regulation, Neoplastic - genetics / Gene Function / Gene sequencing / Genes / Genetic aspects / Genome - genetics / Genomes / Genomics / Human Genetics / Humans / Male / Metastases / Metastasis / Methylation / Methyltransferases / Middle Aged / Mutation / Mutation - genetics / Myc protein / Prospective Studies / Prostate cancer / Prostatic Neoplasms - genetics / Regions / Regulatory sequences / Ribonucleic acid / RNA / Sequence Analysis, DNA - methods / Sulfites / Tumors / Whole Exome Sequencing - methods / Whole Genome Sequencing - methods

2020

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

The DNA methylation landscape of advanced prostate cancer

2020

Confirm

Do you wish to request the book?

The DNA methylation landscape of advanced prostate cancer

2020

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

The DNA methylation landscape of advanced prostate cancer

Li, Haolong,

Huang, Jiaoti,

Bose, Rohit,

Boutros, Paul C.,

Chesner, Lisa,

Hua, Junjie T.,

Moussavi-Baygi, Ruhollah,

Alshalalfa, Mohammed,

Beer, Tomasz M.,

Feng, Felix Y.,

Batzoglou, Serafim,

Gleave, Martin,

Alumkal, Joshi J.,

Barnard, Travis J.,

Evans, Christopher P.,

Dang, Ha X.,

Chi, Kim N.,

Shenoy, Tanushree,

Lara, Primo N.,

He, Housheng H.,

Febbo, Phillip,

Asangani, Irfan A.,

Sjöström, Martin,

Chen, William S.,

Liao, Arnold,

Yvonne Kim, M.,

Rettig, Matthew B.,

Sandhu, Shahneen,

Yang, Rendong,

Laura Chang, S.,

Zwart, Wilbert,

Witte, Owen,

Huang, Franklin W.,

Small, Eric J.,

Morgan, Todd M.,

Chinnaiyan, Arul M.,

Chow, Eric D.,

Tomlins, Scott A.,

Costello, Joseph F.,

Das, Rajdeep,

Zhang, Meng,

Playdle, Denise,

Dehm, Scott M.,

Perry, Marc D.,

Farh, Kyle,

Lang, Joshua M.,

Fong, Lawrence,

Thomas, George,

Luo, Jianhua,

Reiter, Robert E.,

Aggarwal, Rahul,

Maher, Christopher A.,

Mahajan, Nupam P.,

Gilbert, Luke A.,

Ashworth, Alan,

Knudsen, Karen E.,

Foye, Adam,

Houlahan, Kathleen E.,

Zhang, Li,

Zoubeidi, Amina,

Li, Hui,

Wyatt, Alexander W.,

Bailey, Adina M.,

Quigley, David A.,

Zhao, Shuang G.,

Goodarzi, Hani,

Spratt, Da

2020

Overview

Although DNA methylation is a key regulator of gene expression, the comprehensive methylation landscape of metastatic cancer has never been defined. Through whole-genome bisulfite sequencing paired with deep whole-genome and transcriptome sequencing of 100 castration-resistant prostate metastases, we discovered alterations affecting driver genes that were detectable only with integrated whole-genome approaches. Notably, we observed that 22% of tumors exhibited a novel epigenomic subtype associated with hypermethylation and somatic mutations in TET2 , DNMT3B , IDH1 and BRAF . We also identified intergenic regions where methylation is associated with RNA expression of the oncogenic driver genes AR , MYC and ERG . Finally, we showed that differential methylation during progression preferentially occurs at somatic mutational hotspots and putative regulatory regions. This study is a large integrated study of whole-genome, whole-methylome and whole-transcriptome sequencing in metastatic cancer that provides a comprehensive overview of the important regulatory role of methylation in metastatic castration-resistant prostate cancer. Whole-genome bisulfite sequencing along with whole-genome and transcriptome sequencing of 100 prostate cancer metastases identifies genomic regions that are differentially methylated during disease progression and a novel epigenomic subtype.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ Aged

/ Animal Genetics and Genomics