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Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections
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Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections
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Journal Article
Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections
2017
Overview
2-Aminoimidazole (2-AI)-based compounds have been shown to efficiently disrupt biofilm formation, disperse existing biofilms, and resensitize numerous multidrug-resistant bacteria to antibiotics. Using
and
, we provide initial pharmacological studies regarding the application of a 2-AI as a topical adjuvant for persistent dermal infections. In vitro assays indicated that the 2-AI
is nonbactericidal, resensitizes bacteria to antibiotics, does not harm the integument, and promotes wound healing. Furthermore, in vivo application of
on swine skin caused no gross abnormalities or immune reactions. Taken together, these results indicate that
represents a promising lead dermal adjuvant compound.
Publisher
Dove Medical Press Limited,Taylor & Francis Ltd,Dove Press,Dove Medical Press
Subject
/ Anti-Bacterial Agents - administration & dosage
/ Anti-Bacterial Agents - pharmacology
/ Anti-Bacterial Agents - therapeutic use
/ Bacteria
/ Biofilms
/ Dose-Response Relationship, Drug
/ Humans
/ Imidazoles - administration & dosage
/ Imidazoles - therapeutic use
/ Kinases
/ Pseudomonas aeruginosa - drug effects
/ Pseudomonas aeruginosa - growth & development
/ Skin
/ Skin Diseases, Bacterial - drug therapy
/ Staphylococcus aureus - drug effects
/ Staphylococcus aureus - growth & development
/ Structure-Activity Relationship
/ Swine
