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TRYing to evaluate production costs in microbial biotechnology
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Journal Article
TRYing to evaluate production costs in microbial biotechnology
2024
Overview
Microbial fermentations are widely used for the production of chemicals used as pharmaceuticals, food ingredients, materials, solvents, and biofuels.Technoeconomic analysis of a given fermentation process is important to perform before scaling the process to levels that enable commercial production.Titer, rate, and yield (TRY) of the fermentation process are key metrics that are used for technoeconomic analysis.TRY metrics have different impacts on the technoeconomic analysis, and it is important to be aware of these differences.
Microbial fermentations offer the opportunity to produce a wide range of chemicals in a sustainable fashion, but it is important to carefully evaluate the production costs. This can be done on the basis of evaluation of the titer, rate, and yield (TRY) of the fermentation process. Here we describe how the three TRY metrics impact the technoeconomics of a microbial fermentation process, and we illustrate the use of these for evaluation of different processes in the production of two commodity chemicals, 1,3-propanediol (PDO) and ethanol, as well as for the fine chemical penicillin. On the basis of our discussions, we provide some recommendations on how the TRY metrics should be reported when new processes are described.
Microbial fermentations offer the opportunity to produce a wide range of chemicals in a sustainable fashion, but it is important to carefully evaluate the production costs. This can be done on the basis of evaluation of the titer, rate, and yield (TRY) of the fermentation process. Here we describe how the three TRY metrics impact the technoeconomics of a microbial fermentation process, and we illustrate the use of these for evaluation of different processes in the production of two commodity chemicals, 1,3-propanediol (PDO) and ethanol, as well as for the fine chemical penicillin. On the basis of our discussions, we provide some recommendations on how the TRY metrics should be reported when new processes are described.
Publisher
Elsevier Ltd,Elsevier Limited
