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Optogenetics: 10 years of microbial opsins in neuroscience
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Journal Article
Optogenetics: 10 years of microbial opsins in neuroscience
2015
Overview
Over the past decade, modern optogenetics has emerged from the convergence of developments in microbial opsin engineering, genetic methods for targeting, and optical strategies for light delivery. In this Historical Commentary, Karl Deisseroth reflects on the optogenetic landscape, from the important steps but slow progress in the beginning to the acceleration in discovery seen in recent years.
Over the past 10 years, the development and convergence of microbial opsin engineering, modular genetic methods for cell-type targeting and optical strategies for guiding light through tissue have enabled versatile optical control of defined cells in living systems, defining modern optogenetics. Despite widespread recognition of the importance of spatiotemporally precise causal control over cellular signaling, for nearly the first half (2005–2009) of this 10-year period, as optogenetics was being created, there were difficulties in implementation, few publications and limited biological findings. In contrast, the ensuing years have witnessed a substantial acceleration in the application domain, with the publication of thousands of discoveries and insights into the function of nervous systems and beyond. This Historical Commentary reflects on the scientific landscape of this decade-long transition.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animal Genetics and Genomics
/ Animals
/ Bacteriorhodopsins - biosynthesis
/ Bacteriorhodopsins - chemistry
/ Bacteriorhodopsins - genetics
/ Genes
/ Humans
/ Light
/ Opsins
/ Photic Stimulation - methods
/ Protein Structure, Secondary
/ Proteins
/ Rhodopsins, Microbial - biosynthesis
