Asset Details
Do you wish to reserve the book?
Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration
Do you wish to request the book?
Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration
2016
Overview
Polycomb repressive complex 2 (PRC2) is a key mammalian epigenetic regulator that supports neuron specification during development. In this paper, the authors find that PRC2 plays a role in the survival of adult neurons. The loss of PRC2 activity in adult striatum led to the de-repression of multiple genes with bivalent histone methylation marks and to a fatal neurodegeneration phenotype.
Normal brain function depends on the interaction between highly specialized neurons that operate within anatomically and functionally distinct brain regions. Neuronal specification is driven by transcriptional programs that are established during early neuronal development and remain in place in the adult brain. The fidelity of neuronal specification depends on the robustness of the transcriptional program that supports the neuron type-specific gene expression patterns. Here we show that polycomb repressive complex 2 (PRC2), which supports neuron specification during differentiation, contributes to the suppression of a transcriptional program that is detrimental to adult neuron function and survival. We show that PRC2 deficiency in striatal neurons leads to the de-repression of selected, predominantly bivalent PRC2 target genes that are dominated by self-regulating transcription factors normally suppressed in these neurons. The transcriptional changes in PRC2-deficient neurons lead to progressive and fatal neurodegeneration in mice. Our results point to a key role of PRC2 in protecting neurons against degeneration.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 14/28
/ 38
/ 38/39
/ 38/61
/ 38/90
/ Ablation
/ Analysis
/ Animal Genetics and Genomics
/ Animals
/ Female
/ Genes
/ Genomes
/ Histone-Lysine N-Methyltransferase - metabolism
/ Male
/ Mice
/ Nerve Degeneration - genetics
/ Neurodegenerative Diseases - genetics
/ Neurodegenerative Diseases - metabolism
/ Neurons
/ Polycomb Repressive Complex 2 - deficiency
/ Polycomb Repressive Complex 2 - genetics
