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Delay activity of specific prefrontal interneuron subtypes modulates memory-guided behavior
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Delay activity of specific prefrontal interneuron subtypes modulates memory-guided behavior
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Journal Article
Delay activity of specific prefrontal interneuron subtypes modulates memory-guided behavior
2017
Overview
Using calcium imaging and optogenetic manipulation in mice performing a working memory task, the authors show that delay activity in prefrontal cortex pyramidal neurons is crucial for task performance. Optogenetic activation of VIP interneurons enhances the neuronal representation of task-relevant information and improves the animal's memory retention.
Memory-guided behavior requires maintenance of task-relevant information without sensory input, but the underlying circuit mechanism remains unclear. Calcium imaging in mice performing a delayed Go or No-Go task revealed robust delay activity in dorsomedial prefrontal cortex, with different pyramidal neurons signaling Go and No-Go action plans. Inhibiting pyramidal neurons by optogenetically activating somatostatin- or parvalbumin-positive interneurons, even transiently during the delay, impaired task performance, primarily by increasing inappropriate Go responses. In contrast, activating vasoactive intestinal peptide (VIP)-positive interneurons enhanced behavioral performance and neuronal action plan representation. Furthermore, while endogenous activity of somatostatin and parvalbumin neurons was strongly biased toward Go trials, VIP neurons were similarly active in Go and No-Go trials. Somatostatin or VIP neuron activation also impaired or enhanced performance, respectively, in a delayed two-alternative forced-choice task. Thus, dorsomedial prefrontal cortex is a crucial component of the short-term memory network, and activation of its VIP neurons improves memory retention.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 64/60
/ 9/10
/ 96/63
/ Analysis
/ Animal Genetics and Genomics
/ Animals
/ Choice Behavior - physiology
/ Female
/ Male
/ Memory, Short-Term - physiology
/ Mice
/ Neural Inhibition - physiology
/ Prefrontal Cortex - physiology
/ Pyramidal Cells - physiology
/ Vasoactive Intestinal Peptide - metabolism
