Journal Article

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

Cole, Trevor, Breen, Gerome, Ayub, Muhammad, Newbury-Ecob, Ruth, McCarroll, Steve A, Moilanen, Jukka S, Freimer, Nelson B, Kurki, Mitja I, Crooks, Lucy, Walters, James T R, Collier, David, Körkkö, Jarmo, Männikkö, Minna, Holmans, Peter, Iyegbe, Conrad, O'Donovan, Michael C, Foster, Alison, Roberts, David, Singh, Tarjinder, Joss, Shelagh, Hurles, Matthew E, Paunio, Tiina, Sullivan, Patrick F, Daly, Mark J, DiForti, Marta, Coomber, Eve L, Pietiläinen, Olli, Sambrook, Jennifer, Hultman, Christina M, Rees, Elliott, Sklar, Pamela, Gerety, Sebastian S, Veijola, Juha, Clair, David St, Purcell, Shaun M, Suvisaari, Jaana, Kuismin, Outi, Lönnqvist, Jouko, Prigmore, Elena, McQuillin, Andrew, Ouwehand, Willem, Curtis, David, Johnstone, Mandy, Murray, Robin M, Danesh, John, McRae, Jeremy, Chheda, Himanshu, Moore, Carmel, Williams, Hywel, McIntosh, Andrew M, Blyth, Moira, Geschwind, Daniel, Owen, Michael J, Barrett, Jeffrey C, McGuffin, Peter, Palotie, Aarno, Craddock, Nick, Blackwood, Douglas, Kirov, Georg

2016

Overview

The authors analyzed the whole-exome sequences of over 16,000 individuals and found that very rare variants predicted to disrupt the SETD1A gene confer substantial risk for schizophrenia. Damaging variants in SETD1A were also associated with diverse, severe developmental disorders, providing an important genetic link between schizophrenia and other neurodevelopmental disorders. By analyzing the whole-exome sequences of 4,264 schizophrenia cases, 9,343 controls and 1,077 trios, we identified a genome-wide significant association between rare loss-of-function (LoF) variants in SETD1A and risk for schizophrenia ( P = 3.3 × 10 −9 ). We found only two heterozygous LoF variants in 45,376 exomes from individuals without a neuropsychiatric diagnosis, indicating that SETD1A is substantially depleted of LoF variants in the general population. Seven of the ten individuals with schizophrenia carrying SETD1A LoF variants also had learning difficulties. We further identified four SETD1A LoF carriers among 4,281 children with severe developmental disorders and two more carriers in an independent sample of 5,720 Finnish exomes, both with notable neuropsychiatric phenotypes. Together, our observations indicate that LoF variants in SETD1A cause a range of neurodevelopmental disorders, including schizophrenia. Combining these data with previous common variant evidence, we suggest that epigenetic dysregulation, specifically in the histone H3K4 methylation pathway, is an important mechanism in the pathogenesis of schizophrenia.

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: 45/23 / 45/43 / 631/208/176 / 631/208/205/2138 / 631/208/366 / 631/208/514 / 631/378/1689/1799 / Animal Genetics and Genomics / Behavioral Sciences / Biological Techniques / Biomedicine / Case-Control Studies / Child development deviations / Cohort Studies / Developmental disabilities / Exome sequencing / Female / Finland - epidemiology / Genes / Genetic aspects / Genetic Association Studies - methods / Genetic Predisposition to Disease - epidemiology / Genetic Predisposition to Disease - genetics / Genetic variation / Genetic Variation - genetics / Genomes / Health aspects / Histone-Lysine N-Methyltransferase - genetics / Humans / Identification and classification / Male / Methods / Mutation / Neurobiology / Neurodevelopmental Disorders - diagnosis / Neurodevelopmental Disorders - epidemiology / Neurodevelopmental Disorders - genetics / Neurosciences / Pathogenesis / Risk factors / Schizophrenia / Schizophrenia - diagnosis / Schizophrenia - epidemiology / Schizophrenia - genetics