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Effect of topical ropivacaine on the response to endotracheal tube during emergence from general anesthesia: a prospective randomized double-blind controlled study
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Effect of topical ropivacaine on the response to endotracheal tube during emergence from general anesthesia: a prospective randomized double-blind controlled study
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Effect of topical ropivacaine on the response to endotracheal tube during emergence from general anesthesia: a prospective randomized double-blind controlled study
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Journal Article
Effect of topical ropivacaine on the response to endotracheal tube during emergence from general anesthesia: a prospective randomized double-blind controlled study
2018
Overview
Background
The airway reflex such as cough is common accompanied with severe fluctuations of hemodynamics during emergence. This prospective double-blind randomized controlled trial tested the hypothesis that topical ropivacaine may reduce extubation response and postoperative sore throat.
Methods
Fifty-four patients undergoing thyroidectomy were randomly assigned to two groups. The patients in Group R were received 0.75% ropivacaine, which was sprayed on the tracheal mucosa, epiglottis, tongue base, and glottis to achieve uniform surface anesthesia. As control, patients in Group C were received the same volume saline. The primiary outcome was the incidence and grade of cough during peri-extubation.
Results
The incidence (34.62% vs. 76.92%,
P
= 0.002) of cough during extubation were lower in Group R compared to Group C. Meanwhile, the sore throat visual acuity score at 12 h after surgery was lower in Group R than that in Group C (2.00 vs. 3.50,
P
= 0.040).
Conclusion
Topical anesthesia with 0.75% ropivacaine before intubation can significantly reduce the incidence of cough during peri-extubation. Meanwhile, it reduced hemodynamic fluctuations and postoperative throat pain without influence patients recovery.
Trial registration
Chinese Clinical Trial Registry,
ChiCTR1800014412
(date of registration January 2018).
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Adult
/ Airway and respiratory management
/ Anesthesia, General - adverse effects
/ Anesthesia, General - psychology
/ Anesthetics, Local - administration & dosage
/ Complications and side effects
/ Control
/ Cough
/ Emergence Delirium - diagnosis
/ Emergence Delirium - prevention & control
/ Emergence Delirium - psychology
/ Female
/ Humans
/ Hypertension - prevention & control
/ Intubation, Intratracheal - adverse effects
/ Intubation, Intratracheal - psychology
/ Male
/ Medicine
/ Mucosa
/ Pain
/ Patients
/ Pharynx
/ Ropivacaine - administration & dosage
/ Ropivacaine; Anesthesia; Local; Anesthesia Recovery Period; Anesthesia and Analgesia; cough
/ Surgery
/ Trachea
