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The \ComPAS Trial\ combined treatment model for acute malnutrition: study protocol for the economic evaluation
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Journal Article
The \ComPAS Trial\ combined treatment model for acute malnutrition: study protocol for the economic evaluation
2018
Overview
Background
Acute malnutrition is currently divided into severe (SAM) and moderate (MAM) based on level of wasting. SAM and MAM currently have separate treatment protocols and products, managed by separate international agencies. For SAM, the dose of treatment is allocated by the child’s weight. A combined and simplified protocol for SAM and MAM, with a standardised dose of ready-to-use therapeutic food (RUTF), is being trialled for non-inferior recovery rates and may be more cost-effective than the current standard protocols for treating SAM and MAM.
Method
This is the protocol for the economic evaluation of the ComPAS trial, a cluster-randomised controlled, non-inferiority trial that compares a novel combined protocol for treating uncomplicated acute malnutrition compared to the current standard protocol in South Sudan and Kenya. We will calculate the total economic costs of both protocols from a societal perspective, using accounting data, interviews and survey questionnaires. The incremental cost of implementing the combined protocol will be estimated, and all costs and outcomes will be presented as a cost-consequence analysis. Incremental cost-effectiveness ratio will be calculated for primary and secondary outcome, if statistically significant.
Discussion
We hypothesise that implementing the combined protocol will be cost-effective due to streamlined logistics at clinic level, reduced length of treatment, especially for MAM, and reduced dosages of RUTF. The findings of this economic evaluation will be important for policymakers, especially given the hypothesised non-inferiority of the main health outcomes. The publication of this protocol aims to improve rigour of conduct and transparency of data collection and analysis. It is also intended to promote inclusion of economic evaluation in other nutrition intervention studies, especially for MAM, and improve comparability with other studies.
Trial Registration
ISRCTN
30393230
, date: 16/03/2017.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Analysis
/ Child Health Services - economics
/ Child Nutrition Disorders - diagnosis
/ Child Nutrition Disorders - diet therapy
/ Child Nutrition Disorders - economics
/ Child Nutrition Disorders - physiopathology
/ Child Nutritional Physiological Phenomena
/ Community management of acute malnutrition
/ Edema
/ Female
/ Food
/ Humans
/ Infant
/ Infant Nutrition Disorders - diagnosis
/ Infant Nutrition Disorders - diet therapy
/ Infant Nutrition Disorders - economics
/ Infant Nutrition Disorders - physiopathology
/ Kenya
/ Male
/ Malnutrition - physiopathology
/ Medicine
/ Multicenter Studies as Topic
/ Nutrition Therapy - economics
/ Rural Health Services - economics
/ Statistics for Life Sciences
/ Sudan
