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The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19

by Paixão, Enny , Pescarini, Julia M. , Ximenes, Ricardo , Trajman, Anete , da Natividade, Marcio Santos , Pereira, Marcos , Barral-Netto, Manoel , de Souza, Ramon Andrade , Ichihara, Maria Yury , Nunes, Ceuci , Pereira, Susan Martins , Barreto, Maurício L. , Dalcomo, Margareth , Barreto, Florisneide Rodrigues

in Absenteeism / Bacillus Calmette-Guerin vaccine / BCG / BCG Vaccine - immunology / BCG Vaccine - therapeutic use / Clinical outcomes / Clinical trials / Clinical Trials as Topic / Coronavirus Infections - mortality / Coronavirus Infections - prevention & control / Coronavirus Infections - therapy / Coronaviruses / Cost-Benefit Analysis / COVID-19 / COVID-19 diagnostic tests / COVID-19 vaccines / Cytokines / Fatalities / Female / Humans / Immunity (Disease) / Letter to the Editor / Low income groups / Male / Medical personnel / Medicine / Medicine & Public Health / Morbidity / Mortality / Needs Assessment / Older people / Pandemics / Pandemics - prevention & control / Pneumology/Respiratory System / Pneumonia, Viral - mortality / Pneumonia, Viral - prevention & control / Pneumonia, Viral - therapy / Poverty / Prevention / Primary Prevention - methods / Quality Control / Role / Severe acute respiratory syndrome coronavirus 2 / Socioeconomic Factors / Survival Analysis / Testing / Tuberculosis / Vaccination / Vaccination - methods / Vaccination - statistics & numerical data / Vaccines / Viral infections

2020

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The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19

2020

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The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19

2020

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Journal Article

The need for fast-track, high-quality and low-cost studies about the role of the BCG vaccine in the fight against COVID-19

Paixão, Enny,

Pescarini, Julia M.,

Ximenes, Ricardo,

Trajman, Anete,

da Natividade, Marcio Santos,

Pereira, Marcos,

Barral-Netto, Manoel,

de Souza, Ramon Andrade,

Ichihara, Maria Yury,

Nunes, Ceuci,

Pereira, Susan Martins,

Barreto, Maurício L.,

Dalcomo, Margareth,

Barreto, Florisneide Rodrigues

2020

Overview

Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and mortality. This commentary discusses the limitations of the evidence around BCG and COVID-19. We argue that higher-quality evidence is necessary to understand the protective effect of the BCG vaccine from existing, secondary data, while we await results from clinical trials currently conducted in different settings.

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Publisher

BioMed Central,BioMed Central Ltd,Nature Publishing Group,BMC

Subject

Absenteeism

/ Bacillus Calmette-Guerin vaccine

/ BCG

/ BCG Vaccine - immunology

/ BCG Vaccine - therapeutic use

/ Clinical outcomes

/ Clinical trials