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Identification and immunotherapeutic targeting of antigens induced by chemotherapy
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Identification and immunotherapeutic targeting of antigens induced by chemotherapy
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Journal Article
Identification and immunotherapeutic targeting of antigens induced by chemotherapy
2006
Overview
Cancer cells differ from normal cells in their response to chemotherapy. We exploited this dissimilarity by identifying and targeting tumor-specific, cell-surface proteins whose expression is induced by the chemotherapeutic irinotecan (CPT-11; Camptosar). A cytotoxin-armed antibody reactive with one of these drug-induced surface proteins, the LY6D/E48 antigen, originally identified as the target of a monoclonal antibody reactive with squamous cell carcinomas, caused complete regression of colorectal tumor xenografts in mice treated with CPT-11, whereas either agent alone was less effective. These results suggest that a positive therapeutic index may be generated for other drug combinations by immunotherapeutic targeting of chemotherapy-induced antigens.
Publisher
Nature Publishing Group US,Nature,Nature Publishing Group
Subject
/ Animals
/ Antibodies, Monoclonal - immunology
/ Antibodies, Monoclonal - therapeutic use
/ Antigens
/ Antigens, Neoplasm - immunology
/ Antineoplastic Agents - administration & dosage
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Biomedical Engineering/Biotechnology
/ Camptothecin - administration & dosage
/ Camptothecin - analogs & derivatives
/ Cancer
/ Carcinoma, Squamous Cell - drug therapy
/ Carcinoma, Squamous Cell - immunology
/ Cells
/ Drug Delivery Systems - methods
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ letter
/ Membrane Proteins - immunology
/ Mice
/ Pharmacology. Drug treatments
/ Proteins
/ Tumors
