Journal Article

Prophylactic bilateral central neck dissection should be evaluated based on prospective randomized study of 581 PTC patients

Zhang, Liyong, Wang, Bo, Yan, Shouyi, Zhao, Wenxin, Yu, Jiafan

2022

Overview

Background Prophylactic central lymph node dissection (PCND) was a basic consensus for patients with papillary thyroid carcinoma (PTC) in China. However, unilateral or bilateral central lymph node dissection (CND) was still controversial. This study aimed at investigating the safety and long-term benefit for the patients undergone with bilateral central lymph node dissection (BCCD). Methods 581 patients were enrolled and divided randomly into the test and control groups according to range of CND. 285 patients were prospectively assigned to undergo thyroid lobectomy plus BCND in the test group, other 296 patients were assigned to undergo thyroid lobectomy plus ipsilateral central lymph node dissection (ICND) in the control group. Results We found that the numbers of total LN and pN1a in the test group were more than that of the control group ( p  = 0.002,0.004), but there was no difference in the number of metastasized lymph nodes ( p  = 0.857) and tumor recurrence ( p  = 0.308). Additionally, in the aspect of postoperative complication (1 day after surgery), the serum levels of parathyroid hormone in the BCND group were lower than that in the ICND group ( P  = 0.010), and the numbers of transient laryngeal nerve palsy were more than that( p  = 0.033). Meanwhile, we further found that pathological tumor size larger than 1 cm and tumor side lymph node metastasis were independent risk factors for contralateral central lymph node metastasis( p  = 0.002,0.001). Conclusion BCND may be an alternative for patients with tumor sizes larger than 1 cm, but it would significantly increase the rate of transient vocal cord palsy, parathyroid auto transplantation and decreased PTH, but the risk of permanent complications was similar to the ICND group.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Cancer / Central lymph node dissection / Classification / Complications / Diabetes / Dissection / Endocrine system / Endocrinology / Female / Humans / Hypocalcemia / Lymph Node Excision - adverse effects / Lymph nodes / Lymphatic system / Male / Medical research / Medicine / Medicine & Public Health / Medicine, Experimental / Metabolic Diseases / Metastases / Metastasis / Middle Aged / Neck Dissection - adverse effects / Neurological disorders / Outcome Assessment, Health Care / Papillary thyroid cancer / Papillary thyroid carcinoma / Paralysis / Parathyroid / Parathyroid hormone / Parathyroid protection / Patients / Postoperative / Postoperative Complications / Prospective Studies / Research Article / Risk factors / rology / Serum levels / Statistical analysis / Surgeons / Surgery / Thymus gland / Thyroid / Thyroid cancer / Thyroid Cancer, Papillary - surgery / Thyroid gland / Thyroid Neoplasms - surgery / Thyroidectomy / Transplantation / Tumor recurrence / Tumors / Ultrasonic imaging / Veins & arteries