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BRCA1 and homologous recombination: implications from mouse embryonic development
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BRCA1 and homologous recombination: implications from mouse embryonic development
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Journal Article
BRCA1 and homologous recombination: implications from mouse embryonic development
2020
Overview
As an important player in DNA damage response, BRCA1 maintains genomic stability and suppresses tumorigenesis by promoting DNA double-strand break (DSB) repair through homologous recombination (HR). Since the cloning of
BRCA1
gene, many
Brca1
mutant alleles have been generated in mice. Mice carrying homozygous
Brca1
mutant alleles are embryonic lethal, suggesting that BRCA1’s functions are important for embryonic development. Studies of embryonic development in
Brca1
mutant mice not only reveal the physiological significance of BRCA1’s known function in HR, but also lead to the discovery of BRCA1’s new function in HR: regulation of DSB repair pathway choice.
