Journal Article

Malaria prevalence in Mauritania: a systematic review and meta-analysis

Ouldabdallahi Moukah, Mohamed, Briolant, Sébastien, El Moustapha, Inejih, Ould Mohamed Salem Boukhary, Ali, Brahim, Khyarhoum, Ould Ahmedou Salem, Mohamed Salem, Basco, Leonardo

2023

Overview

Background Understanding malaria epidemiology is a critical step toward efficient malaria control and elimination. The objective of this meta-analysis was to derive robust estimates of malaria prevalence and Plasmodium species from studies conducted in Mauritania and published since 2000. Methods The present review followed the PRISMA guidelines. Searches were conducted in various electronic databases such as PubMed, Web of Science, and Scopus. To obtain pooled prevalence of malaria, meta-analysis was performed using the DerSimonian-Laird random-effects model. Methodological quality of eligible prevalence studies was assessed using Joanna Briggs Institute tool. Inconsistency and heterogeneity between studies were quantified by the I 2 index and Cochran’s Q test. Publication bias was assessed with funnel plots and Egger’s regression tests. Results A total of 16 studies with a good individual methodological quality were included and analysed in this study. The overall random effects pooled prevalence of malaria infection (symptomatic and asymptomatic) across all included studies was 14.9% (95% confidence interval [95% CI]: 6.64, 25.80, I 2  = 99.8%, P < 0.0001) by microscopy, 25.6% (95% CI: 8.74, 47.62, I 2  = 99.6%, P < 0.0001) by PCR and 24.3% (95% CI: 12.05 to 39.14, I 2  = 99.7%, P < 0.0001) by rapid diagnostic test. Using microscopy, the prevalence of asymptomatic malaria was 1.0% (95% CI: 0.00, 3.48) against 21.46% (95% CI: 11.03, 34.21) in symptomatic malaria. The overall prevalence of Plasmodium falciparum and Plasmodium vivax was 51.14% and 37.55%, respectively. Subgroup analysis showed significant variation (P = 0.039) in the prevalence of malaria between asymptomatic and symptomatic cases. Conclusion Plasmodium falciparum and P. vivax are widespread in Mauritania. Results of this meta-analysis implies that distinct intervention measures including accurate parasite-based diagnosis and appropriate treatment of confirmed malaria cases are critical for a successful malaria control and elimination programme in Mauritania.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Analysis / Bacteriology / Biomedical and Life Sciences / Biomedicine / Cardiology and cardiovascular system / Cross-sectional studies / Disease control / Emerging diseases / Entomology / Epidemiology / Heterogeneity / Human diseases / Human health and pathology / Humans / Infectious Diseases / Life Sciences / Malaria / Malaria - epidemiology / Malaria, Falciparum - diagnosis / Malaria, Falciparum - epidemiology / Malaria, Vivax - diagnosis / Malaria, Vivax - epidemiology / Mauritania / Mauritania - epidemiology / Meta-analysis / Microbiology / Microbiology and Parasitology / Microscopy / Nucleotide sequence / Parasites / Parasitology / Plasmodium / Plasmodium falciparum / Plasmodium vivax / Prevalence / Public Health / Seasons / Software / Tropical Medicine / Vector-borne diseases / Virology