Journal Article

Application of artificial intelligence to decode the relationships between smell, olfactory receptors and small molecules

Agence Nationale de la Recherche, Projet MULTIMIX, Audouze, Karine, ANR-18-CE21-0006, MULTIMIX,Approche multidisciplinaire pour mieux comprendre la première étape de la perception des arômes en mélange, Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124), Achebouche, Rayane, Tromelin, Anne, Taboureau, Olivier

2022

Overview

Deciphering the relationship between molecules, olfactory receptors (ORs) and corresponding odors remains a challenging task. It requires a comprehensive identification of ORs responding to a given odorant. With the recent advances in artificial intelligence and the growing research in decoding the human olfactory perception from chemical features of odorant molecules, the applications of advanced machine learning have been revived. In this study, Convolutional Neural Network (CNN) and Graphical Convolutional Network (GCN) models have been developed on odorant moleculesodors and odorant molecules-olfactory receptors using a large set of 5955 molecules, 160 odors and 106 olfactory receptors. The performance of such models is promising with a Precision/Recall Area Under Curve of 0.66 for the odorant-odor and 0.91 for the odorant-olfactory receptor GCN models respectively. Furthermore, based on the correspondence of odors and ORs associated for a set of 389 compounds, an odor-olfactory receptor pairwise score was computed for each odor-OR combination allowing to suggest a combinatorial relationship between olfactory receptors and odors. Overall, this analysis demonstrate that artificial intelligence may pave the way in the identification of the smell perception and the full repertoire of receptors for a given odorant molecule.

• Publisher: Nature Publishing Group,CCSD,Nature Publishing Group UK,Nature Portfolio
• Subject: 631/114 / 631/92 / Artificial Intelligence / Biochemistry, Molecular Biology / Food and Nutrition / Humanities and Social Sciences / Humans / Life Sciences / Machine learning / multidisciplinary / Neural networks / Neurons and Cognition / Odorant receptors / Odorants / Odors / Olfactory Perception / Olfactory Receptor Neurons / Receptors, Odorant / Science / Science (multidisciplinary) / Smell
• ISBN: 0008797221000