Journal Article

Motor function is the primary driver of the associations of sarcopenia and physical frailty with adverse health outcomes in community-dwelling older adults

Leurgans, Sue E., Agarwal, Puja, Delbono, Osvaldo, Dawe, Robert J., Schnaider-Beeri, Michal, Buchman, Aron S., Bennett, David A., Wang, Tianhao

2021

Overview

This study tested the hypothesis that sarcopenia and its constituent components, reduced lean muscle mass and impaired motor function, are associated with reduced survival and increased risk of incident disabilities. 1466 community-dwelling older adults underwent assessment of muscle mass with bioelectrical impedance analysis (BIA), grip strength, gait speed and other components of physical frailty and annual self-report assessments of disability. We used Cox proportional hazards models that controlled for age, sex, race, education and height to examine the associations of a continuous sarcopenia metric with the hazard of death and incident disabilities. Mean baseline age was about 80 years old and follow-up was 5.5 years. In a proportional hazards model controlling for age, sex, race, education and baseline sarcopenia, each 1-SD higher score on a continuous sarcopenia scale was associated with lower hazards of death (HR 0.70, 95%CI [0.62, 0.78]), incident IADL (HR 0.80,95%CI [0.70, 0.93]), incident ADL disability (HR 0.80 95%CI [71, 91]) and incident mobility disability (HR 0.81, 95%CI [0.70, 0.93]). Further analyses suggest that grip strength and gait speed rather than muscle mass drive the associations with all four adverse health outcomes. Similar findings were observed when controlling for additional measures used to assess physical frailty including BMI, fatigue and physical activity. Motor function is the primary driver of the associations of sarcopenia and physical frailty with diverse adverse health outcomes. Further work is needed to identify other facets of muscle structure and motor function which together can identify adults at risk for specific adverse health outcomes.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Activities of daily living / Adults / Aged / Aging / Alzheimer's disease / Biology and Life Sciences / Blood & organ donations / Body composition / Complications and side effects / Diagnostic systems / Disability / Editing / Geriatrics / Gerontology / Grip strength / Health aspects / Health care facilities / Health risks / Housing / Hypotheses / Medicine / Medicine and Health Sciences / Movement disorders / Muscle function / Muscles / Musculoskeletal system / Nervous system / Neurodegenerative diseases / Nuclear medicine / Older people / People and Places / Phenotypes / Physiological aspects / Radiology / Research and Analysis Methods / Retirement / Reviews / Risk factors / Sarcopenia / Social services / Strength testing / Walking