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Genetic variants associated with neurodegenerative Alzheimer disease in natural models

by Palacios, Adrián G. , Valdivia, Gonzalo , Ewer, John , Ardiles, Álvaro O. , Salazar, Claudia

in Aging - genetics / Alzheimer Disease - genetics / Alzheimer's disease / Analysis / Animals / Animals, Genetically Modified / APOE / Apolipoproteins / APP / BIOLOGY / Biomedical and Life Sciences / Care and treatment / Cell Biology / Complications and side effects / Degus / Developmental Biology / Disease Models, Animal / DNA Barcoding, Taxonomic / Genetic aspects / Genetic Variation / Genome / Guinea Pigs / Humans / Influence / Life Sciences / Mice / Microbiology / Neurosciences / Plant Sciences / Rats / Review / Sequence Analysis, Protein / Trending themes in neurobiology

2016

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Genetic variants associated with neurodegenerative Alzheimer disease in natural models

by Palacios, Adrián G. , Valdivia, Gonzalo , Ewer, John , Ardiles, Álvaro O. , Salazar, Claudia

2016

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Genetic variants associated with neurodegenerative Alzheimer disease in natural models

by Palacios, Adrián G. , Valdivia, Gonzalo , Ewer, John , Ardiles, Álvaro O. , Salazar, Claudia

2016

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Journal Article

Genetic variants associated with neurodegenerative Alzheimer disease in natural models

Palacios, Adrián G.,

Valdivia, Gonzalo,

Ewer, John,

Ardiles, Álvaro O.,

Salazar, Claudia

2016

Overview

The use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the main biomarkers of neurodegenerative diseases during aging. Here we review some of these models—most of them rodents, focusing especially on the genetic variations in biomarkers for Alzheimer diseases, in order to explain their relationships with variants associated with the occurrence of the disease in humans.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,Sociedad de Biología de Chile,BMC

Subject

Aging - genetics

/ Alzheimer Disease - genetics

/ Alzheimer's disease

/ Analysis

/ Animals

/ Animals, Genetically Modified

/ APOE