Journal Article

A Multicenter, Retrospective Analysis of Long-Term Survival in 255 Dogs With Pheochromocytoma Treated With Alpha-Adrenoreceptor Antagonists or Surgery (2010–2021)

Scudder, Christopher J., Spence, Susanna, Gostelow, Ruth, Seth, Mayank, Gomes, Cláudia, Benchekroun, Ghita, Allerton, Fergus, Hrovat, Alenka, Lamoureux, Anaïs, Pena-Ramos, Jorge, Arenas, Carolina, Leal, Rodolfo O., Steele, Matthew M. E., Caulfield, Sarah J., Yu Foo, Fang, Carranza Valencia, Alejandra, Lyssens, Aurélie, Fawsitt, Jack, Boag, Alisdair, Galac, Sara, Mendoza, Beatriz, Mooney, Carmel T., Cervone, Mario, Valiente, Paula, van den Berg, Marit F., Lloyd-Bradley, Ben, Heilmann, Romy M., Silverstrini, Paolo, Fracassi, Federico, Olivares, Gerard, Piekos, Karolina Maria, Keyte, Sophie, Dordio, Ana M., Nolff, Mirja, Sieber-Ruckstuhl, Nadja, Vangrinsven, Emilie, Casas-Acuna, Clara, Ruiz, Guillame, Paul, Amanda, Threlfall, Anna

2025

Overview

Abstract Background The survival of dogs with pheochromocytoma (PCC) treated with adrenoreceptor antagonists has not been described or compared to surgically managed cases. Hypothesis/Objectives The objective of this study is to evaluate the survival of medically and surgically managed dogs with PCC and investigate factors associated with survival. Animals Two hundred fifty-five dogs with PCC, treated with alpha-adrenoreceptor antagonists (AA) without adrenalectomy (Group 1, n = 75), adrenalectomy +/– AA (Group 2, n = 128), or neither treatment (Group 3, n = 52). Methods Retrospective, multicenter review of medical records. Median overall survival time (OST) for Groups 1 and 2 combined was calculated using Kaplan–Meier estimates, and then compared between Group 1 and Group 2 using Log-Rank testing. Cox proportional hazard analysis identified factors associated with survival in Groups 1 and 2 individually and combined. Results Median OST for all cases was 854 (95% CI: 572–1136) days. Median OST was lower in Group 1 (247 days, 95% CI: 76–418 days) than in Group 2 (927 days, 95% CI: 587–1267 days; p < 0.001). In Group 2, 88/92 dogs (97.8%) that received presurgical AA treatment survived to discharge compared to 23/27 (85.2%) that did not receive AA pretreatment (p = 0.03). Lack of clinical signs at presentation was associated with increased survival in both groups combined (HR 0.5; 95% CI 0.3–0.9; p = 0.02) and in Group 2 alone (HR 0.3; 95% CI 0.1–0.7; p = 0.01). Conclusions and Clinical Importance Dogs with PCC treated with adrenalectomy have longer survival compared to those managed with AA without adrenalectomy.

• Publisher: Oxford University Press,John Wiley & Sons, Inc,Wiley,John Wiley and Sons Inc
• Subject: Abdomen / adrenal / Adrenal Gland Neoplasms / Adrenal Gland Neoplasms - drug therapy / Adrenal Gland Neoplasms - mortality / Adrenal Gland Neoplasms - surgery / Adrenal Gland Neoplasms - veterinary / adrenalectomy / Adrenalectomy - veterinary / Adrenergic alpha-Antagonists / Adrenergic alpha-Antagonists - therapeutic use / Animal biology / Animals / Blood pressure / Creatinine / Cushing syndrome / Dog Diseases / Dog Diseases - drug therapy / Dog Diseases - mortality / Dog Diseases - surgery / Dogs / endocrine / Female / hazard characterization / Histopathology / Immunohistochemistry / Internal medicine / Iodine / Laboratories / Life Sciences / Male / Medicine / metanephrine / Missing data / Médecine vétérinaire & santé animale / phenoxybenzamine / Pheochromocytoma / Pheochromocytoma - drug therapy / Pheochromocytoma - mortality / Pheochromocytoma - surgery / Pheochromocytoma - veterinary / Radiation therapy / Regression analysis / Retrospective Studies / Risk factors / Sciences du vivant / STANDARD ARTICLE / Statistical analysis / Survival Analysis / Tumors / Variables / Veterinary (all) / veterinary medicine / Veterinary medicine & animal health / Veterinary medicine and animal Health