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NIR-II nanoprobes for investigating the glymphatic system function under anesthesia and stroke injury
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NIR-II nanoprobes for investigating the glymphatic system function under anesthesia and stroke injury
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Journal Article
NIR-II nanoprobes for investigating the glymphatic system function under anesthesia and stroke injury
2024
Overview
The glymphatic system plays an important role in the transportation of cerebrospinal fluid (CSF) and the clearance of metabolite waste in brain. However, current imaging modalities for studying the glymphatic system are limited. Herein, we apply NIR-II nanoprobes with non-invasive and high-contrast advantages to comprehensively explore the function of glymphatic system in mice under anesthesia and cerebral ischemia–reperfusion injury conditions. Our results show that the supplement drug dexmedetomidine (Dex) enhances CSF influx in the brain, decreases its outflow to mandibular lymph nodes, and leads to significant differences in CSF accumulation pattern in the spine compared to isoflurane (ISO) alone, while both ISO and Dex do not affect the clearance of tracer-filled CSF into blood circulation. Notably, we confirm the compromised glymphatic function after cerebral ischemia–reperfusion injury, leading to impaired glymphatic influx and reduced glymphatic efflux. This technique has great potential to elucidate the underlying mechanisms between the glymphatic system and central nervous system diseases.
Graphical Abstract
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
Advanced 2D nanomaterials for biomedical applications
/ Analysis
/ Animals
/ Cerebrospinal Fluid - chemistry
/ Cerebrospinal Fluid - metabolism
/ Chemistry and Materials Science
/ Complications and side effects
/ Dexmedetomidine - pharmacology
/ Glymphatic enhancer dexmedetomidine
/ Glymphatic System - metabolism
/ Glymphatic system in rodent model
/ Male
/ Mice
/ Reperfusion Injury - metabolism
/ Stroke
