Journal Article

Advances in immunotherapy for triple-negative breast cancer

Yi, Jiang, Hu, Yueting, Li, Jingying, Xue, Jinqi, Qiu, Peng, Bu, Jiawen, Liu, Yang, Zhang, Zhenyong, Gu, Xi

2023

Overview

Background Immunotherapy has recently emerged as a treatment strategy which stimulates the human immune system to kill tumor cells. Tumor immunotherapy is based on immune editing, which enhances the antigenicity of tumor cells and increases the tumoricidal effect of immune cells. It also suppresses immunosuppressive molecules, activates or restores immune system function, enhances anti-tumor immune responses, and inhibits the growth f tumor cell. This offers the possibility of reducing mortality in triple-negative breast cancer (TNBC). Main body Immunotherapy approaches for TNBC have been diversified in recent years, with breakthroughs in the treatment of this entity. Research on immune checkpoint inhibitors (ICIs) has made it possible to identify different molecular subtypes and formulate individualized immunotherapy schedules. This review highlights the unique tumor microenvironment of TNBC and integrates and analyzes the advances in ICI therapy. It also discusses strategies for the combination of ICIs with chemotherapy, radiation therapy, targeted therapy, and emerging treatment methods such as nanotechnology, ribonucleic acid vaccines, and gene therapy. Currently, numerous ongoing or completed clinical trials are exploring the utilization of immunotherapy in conjunction with existing treatment modalities for TNBC. The objective of these investigations is to assess the effectiveness of various combined immunotherapy approaches and determine the most effective treatment regimens for patients with TNBC. Conclusion This review provides insights into the approaches used to overcome drug resistance in immunotherapy, and explores the directions of immunotherapy development in the treatment of TNBC.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Acidosis / Analysis / Androgens / Antigenicity / Antigens / Apoptosis / Biomedical and Life Sciences / Biomedicine / Breast cancer / Cancer / Cancer Research / Cancer therapies / Chemokines / Chemotherapy / Clinical trials / Cytokines / Cytotoxicity / Drug resistance / Drug therapy / Fibroblasts / Gene therapy / Growth factors / Health aspects / Hypoxia / Immune checkpoint / Immune checkpoint inhibitors / Immune response / Immunotherapy / Kinases / Lymphocytes / Medical prognosis / Metabolites / Metastasis / Microbiota / Molecular understanding and clinical aspects of immunotherapy in the treatment of cancer / Mortality / Oncology / Oxidative stress / Phytochemicals / Radiation therapy / Radiotherapy / Review / Stem cells / Triple-negative breast cancer / Tumor cells / Tumor microenvironment / Tumor necrosis factor-TNF / Tumors