Journal Article

Association of gastric lymphofollicular hyperplasia with Helicobacter‐like organisms in dogs

Rodrigues, Nina Fernandes, De Carvalho, Rodolfo Elvas, Leal, Rodolfo Oliveira, Domínguez‐Ruiz, Marina, Dally, Claire, Biénès, Tom, Husson, Jean‐Charles, Le Boedec, Kevin, Hernandez, Juan

2022

Overview

Background The relationships among gastric lymphoid follicular hyperplasia (GLFH), Helicobacter‐like organisms (HLOs), and clinical signs have not been established in dogs. Objectives To evaluate the epidemiologic, clinical, endoscopic, and histopathologic findings associated with GLFH in dogs, and determine the association of GLFH with HLOs and the French Bulldog (FB) breed. Animals Two hundred eighty‐eight dogs that underwent gastroscopy between 2013 and 2016. Methods Retrospective, cross‐sectional study. Gastric biopsy samples were reviewed and scored for inflammation and HLOs. Dogs were divided into 3 groups: group 1 (63 FBs), group 2 (45 non‐FB brachycephalic dogs), and group 3 (180 nonbrachycephalic dogs). Variables were evaluated for their association with GLFH. Results Univariate analysis determined that intact males, young age, vomiting, gastroscopic findings (discoloration, hemorrhage, and ulcers), and histopathologic findings (gastric lamina propria lymphocytic infiltration and HLO score) were associated with GLFH (P ≤ .03). In the multivariate analysis, GLFH was associated with the HLO score (odds ratio [OR] > 5 for HLO scores 1‐2 and >15 for HLO score of 3; P < .001), with vomiting (OR > 4; P = .01) but not with FB breed (P = .76) and age (P = .1). The HLO score was associated with younger age (P < .001). Conclusion and Clinical Importance The HLO score was associated with a high GLFH score. Vomiting was associated with GLFH. Helicobacter‐like organisms are highly prevalent in young dogs and GLFH is indirectly associated with this factor. Clinical relevance of the identification of GLFH and HLO remains to be determined.

• Publisher: John Wiley & Sons, Inc,Wiley,John Wiley and Sons Inc
• Subject: Age / Animal biology / Animals / bacterial / bacterial species / Biochemistry, Molecular Biology / Biopsy / chronic gastritis / Cross-Sectional Studies / discoloration / dog / Dog Diseases / Dog Diseases - diagnosis / Dogs / Endoscopy / Foreign bodies / French Bulldog / gastric follicular hyperplasia / Gastric Mucosa / Gastric Mucosa - pathology / Gastritis / Gastritis - veterinary / gastroenterology / Gastroscopy / Gastroscopy - veterinary / General Veterinary / Helicobacter / Helicobacter Infections / Helicobacter Infections - pathology / Helicobacter Infections - veterinary / hemorrhage / Histopathology / Hyperplasia / Hyperplasia - pathology / Hyperplasia - veterinary / Infections / inflammation / Life Sciences / Lymphocytes / Male / Medical records / microbiology / Microbiology and Parasitology / multivariate analysis / Médecine vétérinaire & santé animale / Neutrophils / odds ratio / Retrospective Studies / Sciences du vivant / SMALL ANIMAL / Standardization / Statistical analysis / Variables / Veterinary (all) / veterinary medicine / Veterinary medicine & animal health