Journal Article

Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography

Bakker, Guido J., Zwinderman, Aeilko H., Pinto-Sietsma, Sara-Joan, Tremaroli, Valentina, Bouter, Kristien E., Snijder, Marieke B., Bäckhed, Fredrik, Prodan, Andrei, Attaye, Ilias, Nieuwdorp, Max, Herrema, Hilde, Levin, Evgeni, Deschasaux, Mélanie, Groen, Albert K., Peters, Ron, Nicolaou, Mary, van Raalte, Daniel H.

2018

Overview

Trillions of microorganisms inhabit the human gut and are regarded as potential key factors for health 1 , 2 . Characteristics such as diet, lifestyle, or genetics can shape the composition of the gut microbiota 2 – 6 and are usually shared by individuals from comparable ethnic origin. So far, most studies assessing how ethnicity relates to the intestinal microbiota compared small groups living at separate geographical locations 7 – 10 . Using fecal 16S ribosomal RNA gene sequencing in 2,084 participants of the Healthy Life in an Urban Setting (HELIUS) study 11 , 12 , we show that individuals living in the same city tend to share similar gut microbiota characteristics with others of their ethnic background. Ethnicity contributed to explain the interindividual dissimilarities in gut microbiota composition, with three main poles primarily characterized by operational taxonomic units (OTUs) classified as Prevotella (Moroccans, Turks, Ghanaians), Bacteroides (African Surinamese, South-Asian Surinamese), and Clostridiales (Dutch). The Dutch exhibited the greatest gut microbiota α-diversity and the South-Asian Surinamese the smallest, with corresponding enrichment or depletion in numerous OTUs. Ethnic differences in α-diversity and interindividual dissimilarities were independent of metabolic health and only partly explained by ethnic-related characteristics including sociodemographic, lifestyle, or diet factors. Hence, the ethnic origin of individuals may be an important factor to consider in microbiome research and its potential future applications in ethnic-diverse societies. Stool microbiota composition correlates with the ethnic backgrounds of people living in the same city, suggesting that geographical location and ethnicity have distinct effects on microbiota.

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: 631/326/2565/2134 / 692/308/174 / Africa - epidemiology / age / Bacteroides - classification / Bacteroides - genetics / Bacteroides - isolation & purification / Biochemistry & Molecular Biology / Biodiversity / Biomedical and Life Sciences / Biomedicine / Cancer Research / Cell Biology / Clostridiales - classification / Clostridiales - genetics / Clostridiales - isolation & purification / Comparative analysis / Composition / Demographic aspects / Diet / Digestive system / disease / diversity / enterotypes / Ethnic factors / Ethnicity / Ethnicity - classification / Ethnicity - genetics / Feces - microbiology / Female / Food and Nutrition / Gastroenterologi och hepatologi / Gastroenterology and Hepatology / Gastrointestinal Microbiome - genetics / Gastrointestinal tract / Gene sequencing / Genes / Genetics / Genetics, Population / Geography / glucose-metabolism / health / Health aspects / Humans / Infectious Diseases / Intestinal microflora / Intestine / Letter / Life Sciences / Male / markers / Medicine / Metabolic Diseases / Microbiomes / Microbiota / Microbiota (Symbiotic organisms) / Microbiota - genetics / Microorganisms / Minority & ethnic groups / Molecular Medicine / Netherlands - epidemiology / Neurosciences / Physical fitness / Physiological aspects / Research & Experimental / Ribonucleic acid / Ribosomal RNA / Risk Factors / RNA / RNA, Ribosomal, 16S - genetics / rRNA 16S / Santé publique et épidémiologie / Type 2 diabetes / Urban areas / Urban population