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Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation
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Journal Article
Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation
2018
Overview
Lysyl oxidase-like 2 (LOXL2) is a copper-dependent monoamine oxidase that contributes to the remodelling of the extracellular matrix (ECM) by cross linkage of collagen and elastin fibres and has emerged as a potential therapeutic target in cancer and fibrosis. In the skin, LOXL2 is essential for epidermal cell polarity and differentiation. However, its role in the dermis has not been evaluated. We found that Loxl2 is dispensable for mouse dermal development, maturation and homeostasis, yet affects dermal stiffness. Neither loss of Loxl2 nor increased Loxl2 expression affected dermal architecture following treatment with the phorbol ester TPA. Furthermore, Loxl2 expression did not alter the stroma of DMBA-TPA-induced tumours. We conclude that, although Loxl2 is expressed in both dermis and epidermis, its function appears largely confined to the epidermis.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Amine oxidase (flavin-containing)
/ Amino Acid Oxidoreductases - genetics
/ Amino Acid Oxidoreductases - metabolism
/ Animals
/ Cancer
/ Collagen
/ Copper
/ Dermis
/ Elastin
/ Extracellular Matrix - enzymology
/ Extracellular Matrix - genetics
/ Extracellular Matrix - pathology
/ Fibers
/ Fibrosis
/ Genomics
/ Humans
/ Medicine
/ Medicine and Health Sciences
/ Mice
/ Neoplasm Proteins - genetics
/ Neoplasm Proteins - metabolism
/ Oxidase
/ Polarity
/ Research and Analysis Methods
/ Skin
/ Stroma
/ Tetradecanoylphorbol Acetate - toxicity
/ Tumors
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