Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy

by Frias, Antonio E. , Grafe, Marjorie R. , Stenzel, Peter , Renner, Lauren M. , Smith, Jessica L. , Morgan, Terry K. , Steinbach, Rosemary J. , Houser, Lisa A. , Kempton, J. Beth , Andoh, Takeshi F. , Streblow, Daniel Neal , Pecoraro, Heidi L. , Wang, Xiaojie , Lewis, Anne D. , Colgin, Lois M. A. , Hirsch, Alec J. , Sacha, Jonah B. , McGill, Trevor J. , Hodge, Travis , Kelleher, Meredith A. , Friedman, Robert M. , Schelonka, Robert L. , Brigande, John V. , Kroenke, Christopher D. , Haese, Nicole N. , Dozier, Brandy L. , Roberts, Victoria H. J. , Parkins, Christopher J. , Neuringer, Martha , Kreklywich, Craig N. , Lindner, Jonathan R. , MacAllister, Rhonda P. , Greene, Justin M. , Porsov, Edward

in Abnormalities / Abortion / Animals / Biology and life sciences / Cardiomyopathies - virology / Cardiomyopathy / Clinical medicine / Congenital defects / Congenital diseases / Delay / Disease Models, Animal / Epidemics / Female / Fetus - virology / Fetuses / Gene therapy / Genetic disorders / Guillain-Barre syndrome / Gynecology / Hearing loss / Immunology / Infection / Infections / Levetiracetam / Macaca mulatta / Medicine / Medicine and Health Sciences / Microcephaly - virology / Microencephaly / Miscarriage / Myocardial diseases / Neonates / Neurodevelopmental disorders / Neurosciences / Newborn babies / Newborn infants / Obstetrics / Otolaryngology / Pathology / Pregnancy / Pregnancy Complications, Infectious - veterinary / Pregnancy Complications, Infectious - virology / Pregnancy Trimester, First / Pregnant women / Primates / Research and Analysis Methods / Seizures / Seizures (Medicine) / Seizures - virology / Supervision / Symptomology / Therapeutics / Vaccines / Vector-borne diseases / Virus diseases / Viruses / Zika virus / Zika Virus - pathogenicity / Zika Virus Infection - veterinary / Zika Virus Infection - virology

2020

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy

2020

Confirm

Do you wish to request the book?

A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy

2020

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy

Frias, Antonio E.,

Grafe, Marjorie R.,

Stenzel, Peter,

Renner, Lauren M.,

Smith, Jessica L.,

Morgan, Terry K.,

Steinbach, Rosemary J.,

Houser, Lisa A.,

Kempton, J. Beth,

Andoh, Takeshi F.,

Streblow, Daniel Neal,

Pecoraro, Heidi L.,

Wang, Xiaojie,

Lewis, Anne D.,

Colgin, Lois M. A.,

Hirsch, Alec J.,

Sacha, Jonah B.,

McGill, Trevor J.,

Hodge, Travis,

Kelleher, Meredith A.,

Friedman, Robert M.,

Schelonka, Robert L.,

Brigande, John V.,

Kroenke, Christopher D.,

Haese, Nicole N.,

Dozier, Brandy L.,

Roberts, Victoria H. J.,

Parkins, Christopher J.,

Neuringer, Martha,

Kreklywich, Craig N.,

Lindner, Jonathan R.,

MacAllister, Rhonda P.,

Greene, Justin M.,

Porsov, Edward

2020

Overview

Zika virus infection during pregnancy is associated with miscarriage and with a broad spectrum of fetal and neonatal developmental abnormalities collectively known as congenital Zika syndrome (CZS). Symptomology of CZS includes malformations of the brain and skull, neurodevelopmental delay, seizures, joint contractures, hearing loss and visual impairment. Previous studies of Zika virus in pregnant rhesus macaques (Macaca mulatta) have described injury to the developing fetus and pregnancy loss, but neonatal outcomes following fetal Zika virus exposure have yet to be characterized in nonhuman primates. Herein we describe the presentation of rhesus macaque neonates with a spectrum of clinical outcomes, including one infant with CZS-like symptoms including cardiomyopathy, motor delay and seizure activity following maternal infection with Zika virus during the first trimester of pregnancy. Further characterization of this neonatal nonhuman primate model of gestational Zika virus infection will provide opportunities to evaluate the efficacy of pre- and postnatal therapeutics for gestational Zika virus infection and CZS.

Share this book

Add to My Shelf

Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

Abnormalities

/ Abortion

/ Animals

/ Biology and life sciences

/ Cardiomyopathies - virology

/ Cardiomyopathy

/ Clinical medicine