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miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis
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miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis
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Journal Article
miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis
2008
Overview
This study demonstrates that several microRNA species co-regulate the levels of the
ataxin1
, a gene implicated in the development of spinocerebellar ataxia type 1 (SCA1). With
ataxin1
dosage contributing to disease severity, this regulation pathway may influence SCA1 progression.
Spinocerebellar ataxia type 1 is caused by expansion of a translated CAG repeat in ataxin1 (ATXN1). The level of the polyglutamine-expanded protein is one of the factors that contributes to disease severity. Here we found that miR-19, miR-101 and miR-130 co-regulate ataxin1 levels and that their inhibition enhanced the cytotoxicity of polyglutamine-expanded ATXN1 in human cells. We provide a new candidate mechanism for modulating the pathogenesis of neurodegenerative diseases sensitive to protein dosage.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Ataxia
/ Ataxin-1
/ Ataxins
/ Biomedical and Life Sciences
/ Disease
/ Gene Expression Regulation - genetics
/ Green Fluorescent Proteins - genetics
/ Green Fluorescent Proteins - metabolism
/ Humans
/ Mice
/ Nerve Tissue Proteins - genetics
/ Nerve Tissue Proteins - metabolism
/ Nuclear Proteins - metabolism
/ Proteins
/ Purkinje Cells - drug effects
/ RNA, Small Interfering - pharmacology
/ Spinocerebellar Ataxias - genetics
