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High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

by Werfel, Thomas , Heim, Katharina , Rodríguez, Elke , Zuo, Xianbo , Michel, Sven , Winkelmann, Juliane , Schreiber, Stefan , Schaarschmidt, Heidi , Kubo, Michiaki , Takahashi, Atsushi , Novak, Natalija , Nakamura, Yusuke , Hübner, Norbert , Büning, Carsten , Irvine, Alan D , Zhang, Xuejun , Hirota, Tomomitsu , Brand, Stephan , Fölster-Holst, Regina , Stuart, Philip , Franke, Andre , Ellinghaus, David , Kabesch, Michael , Baurecht, Hansjörg , Elder, James T , Hoffmann, Per , McLean, W H Irwin , Prokisch, Holger , Brown, Sara , Maintz, Laura , Yang, Sen , Illig, Thomas , Boehm, Bernhard O , Glas, Jürgen , Tamari, Mayumi , Tsoi, Lam C , Nöthen, Markus M , Matanovic, Anja , Meyer-Hoffert, Ulf , Sun, Liangdan , Weidinger, Stephan , Marenholz, Ingo , Esparza-Gordillo, Jorge , Hotze, Melanie , McAleer, Maeve A , Duerr, Richard H , Fahy, Caoimhe M , Lee, Young-Ae , Herder, Christian

in 631/208/205/2138 / 631/208/248 / Agriculture / Analysis / Animal Genetics and Genomics / Asian People - genetics / Asthma / Atopic dermatitis / Biomedicine / Cancer Research / Case-Control Studies / Colleges & universities / Dermatitis / Dermatitis, Atopic - ethnology / Dermatitis, Atopic - genetics / Disease susceptibility / Experiments / Female / Filaggrin Proteins / Gene Function / Gene loci / Genetic aspects / Genetic Loci - genetics / Genetic Predisposition to Disease - ethnology / Genetic Predisposition to Disease - genetics / Genome-Wide Association Study / Genomes / Genotype / Genotyping Techniques / Germany / Grants / Health aspects / High-Throughput Nucleotide Sequencing / Human Genetics / Humans / Immune system / Intermediate Filament Proteins - genetics / Japan / letter / Male / Meta-Analysis as Topic / Mutation / Polymorphism, Single Nucleotide / Proteomics / Psoriasis / Risk factors / Skin diseases / White People - genetics

2013

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High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

2013

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2013

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Journal Article

High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

Werfel, Thomas,

Heim, Katharina,

Rodríguez, Elke,

Zuo, Xianbo,

Michel, Sven,

Winkelmann, Juliane,

Schreiber, Stefan,

Schaarschmidt, Heidi,

Kubo, Michiaki,

Takahashi, Atsushi,

Novak, Natalija,

Nakamura, Yusuke,

Hübner, Norbert,

Büning, Carsten,

Irvine, Alan D,

Zhang, Xuejun,

Hirota, Tomomitsu,

Brand, Stephan,

Fölster-Holst, Regina,

Stuart, Philip,

Franke, Andre,

Ellinghaus, David,

Kabesch, Michael,

Baurecht, Hansjörg,

Elder, James T,

Hoffmann, Per,

McLean, W H Irwin,

Prokisch, Holger,

Brown, Sara,

Maintz, Laura,

Yang, Sen,

Illig, Thomas,

Boehm, Bernhard O,

Glas, Jürgen,

Tamari, Mayumi,

Tsoi, Lam C,

Nöthen, Markus M,

Matanovic, Anja,

Meyer-Hoffert, Ulf,

Sun, Liangdan,

Weidinger, Stephan,

Marenholz, Ingo,

Esparza-Gordillo, Jorge,

Hotze, Melanie,

McAleer, Maeve A,

Duerr, Richard H,

Fahy, Caoimhe M,

Lee, Young-Ae,

Herder, Christian

2013

Overview

Andre Franke and colleagues perform an association study of atopic dermatitis based on high-density genotyping using the Immunochip array. They identify four new susceptibility loci for this common inflammatory skin disease. Atopic dermatitis is a common inflammatory skin disease with a strong heritable component. Pathogenetic models consider keratinocyte differentiation defects and immune alterations as scaffolds 1 , and recent data indicate a role for autoreactivity in at least a subgroup of patients 2 . FLG (encoding filaggrin) has been identified as a major locus causing skin barrier deficiency 3 . To better define risk variants and identify additional susceptibility loci, we densely genotyped 2,425 German individuals with atopic dermatitis (cases) and 5,449 controls using the Immunochip array followed by replication in 7,196 cases and 15,480 controls from Germany, Ireland, Japan and China. We identified four new susceptibility loci for atopic dermatitis and replicated previous associations. This brings the number of atopic dermatitis risk loci reported in individuals of European ancestry to 11. We estimate that these susceptibility loci together account for 14.4% of the heritability for atopic dermatitis.

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ Animal Genetics and Genomics

/ Asian People - genetics

/ Asthma