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Chase-and-run between adjacent cell populations promotes directional collective migration
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Journal Article
Chase-and-run between adjacent cell populations promotes directional collective migration
2013
Overview
Collective cell migration in morphogenesis and cancer progression often involves the coordination of multiple cell types. How reciprocal interactions between adjacent cell populations lead to new emergent behaviours remains unknown. Here we studied the interaction between neural crest (NC) cells, a highly migratory cell population, and placodal cells, an epithelial tissue that contributes to sensory organs. We found that NC cells chase placodal cells by chemotaxis, and placodal cells run when contacted by NC. Chemotaxis to Sdf1 underlies the chase, and repulsion involving PCP and N-cadherin signalling is responsible for the run. This chase-and-run requires the generation of asymmetric forces, which depend on local inhibition of focal adhesions. The cell interactions described here are essential for correct NC migration and for segregation of placodes
in vivo
and are likely to represent a general mechanism of coordinated migration.
Mayor and colleagues observed that placodal cell movements in
Xenopus
and zebrafish embryos are controlled by their interaction with adjacent neural crest cells. Neural crest cells chemotactically migrated towards placodal cells and, on contact, induced neural crest cells to migrate away, revealing a ‘chase-and-run’ behaviour.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Ablation
/ Animals
/ Behavior
/ Biology
/ Cancer
/ Cell Communication - physiology
/ Chemokine CXCL12 - metabolism
/ Embryo, Mammalian - cytology
/ Embryo, Mammalian - metabolism
/ Epithelial Cells - metabolism
/ Focal Adhesions - physiology
/ Guanine Nucleotide Exchange Factors - metabolism
/ Mice
