Journal Article

Sleep and allergic diseases among young Chinese adults from the Singapore/Malaysia Cross-Sectional Genetic Epidemiology Study (SMCGES) cohort

Ng, Jun Yan, Lim, Yi Ying Eliza, Wong, Qi Yi Ambrose, Chew, Fook Tim, Sio, Yang Yie, Lim, Jun Jie

2024

Overview

Background and objective Sleep disruption has been shown to affect immune function and thus influence allergic disease manifestation. The specific effects of sleep on allergic diseases, however, are less well-established; hence, in a unique population of young Chinese adults, we investigated the association between sleep and allergic disease. Methods Young Chinese adults recruited from Singapore in the Singapore/Malaysia Cross-Sectional Genetic Epidemiology Study (SMCGES) were analyzed. We used the International Study of Asthma and Allergies in Childhood (ISAAC) protocol and a skin prick test to determine atopic dermatitis (AD), allergic rhinitis (AR), and asthma status. Information regarding total sleep time (TST) and sleep quality (SQ) was also obtained. Results Of 1558 participants with a mean age of 25.0 years (SD = 7.6), 61.4% were female, and the mean total sleep time (TST) was 6.8 h (SD = 1.1). The proportions of AD, AR, and asthma were 24.5% (393/1542), 36.4% (987/1551), and 14.7% (227/1547), respectively. 59.8% (235/393) of AD cases suffered from AD-related sleep disturbances, 37.1% (209/564) of AR cases suffered from AR-related sleep disturbances, and 25.1% (57/227) of asthma cases suffered from asthma-related sleep disturbances. Only asthma cases showed a significantly lower mean TST than those without asthma ( p  = 0.015). Longer TST was significantly associated with lower odds of AR (OR = 0.905, 95% CI = 0.820–0.999) and asthma (OR = 0.852, 95% CI = 0.746–0.972). Linear regression analyses showed that lower TST was significantly associated with asthma ( β  =  − 0.18, SE = 0.076, p -value = 0.017), and AR when adjusted for AR-related sleep disturbances ( β  =  − 0.157, SE = 0.065, p -value = 0.016). Only sleep disturbances due to AR were significantly associated with a poorer SQ (OR = 1.962, 95% CI = 1.245–3.089). Conclusions We found that sleep quality, but not sleep duration was significantly poorer among AD cases, although the exact direction of influence could not be determined. In consideration of the literature coupled with our findings, we posit that TST influences allergic rhinitis rather than vice versa. Finally, the association between TST and asthma is likely mediated by asthma-related sleep disturbances, since mean TST was significantly lower among those with nighttime asthma symptoms. Future studies could consider using objective sleep measurements coupled with differential expression analysis to investigate the pathophysiology of sleep and allergic diseases.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Adults / Advertising executives / Allergic diseases / Allergic rhinitis / Allergy / Analysis / Anthropology / Asthma / Asthma - epidemiology / Asthma - genetics / Atopic dermatitis / Biomedical and Life Sciences / Biomedicine / Children / China / Circadian rhythm / Cross-Sectional Studies / Data collection / Dermatitis / Dermatitis, Atopic - epidemiology / Dermatitis, Atopic - genetics / Disease / Epidemiology / Ethnicity / Female / Hay fever / Human Physiology / Humans / Immune response / ISAAC / Malaysia / Male / Melatonin / Minority & ethnic groups / Molecular Epidemiology / Original / Original Article / Physiology / Questionnaires / Remission (Medicine) / Rhinitis / Rhinitis, Allergic - complications / Rhinitis, Allergic - epidemiology / Singapore - epidemiology / Skin tests / Sleep / Sleep and Circadian rhythm: Adaptation to environment / Sleep apnea / Sleep disorders / Testing