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FAAH selectively influences placebo effects
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Journal Article
FAAH selectively influences placebo effects
2014
Overview
Endogenous opioid and cannabinoid systems are thought to act synergistically regulating antinociceptive and reward mechanisms. To further understand the human implications of the interaction between these two systems, we investigated the role of the common, functional missense variant Pro129Thr of the gene coding
fatty acid amide hydrolase
(
FAAH
), the major degrading enzyme of endocannabinoids, on psychophysical and neurotransmitter (dopaminergic, opioid) responses to pain and placebo-induced analgesia in humans.
FAAH
Pro129/Pro129 homozygotes, who constitute nearly half of the population, reported higher placebo analgesia and more positive affective states immediately and 24 h after placebo administration; no effects on pain report in the absence of placebo were observed. Pro129/Pro129 homozygotes also showed greater placebo-induced μ-opioid, but not D
2/3
dopaminergic, enhancements in neurotransmission in regions known involved in placebo effects. These results show that a common genetic variation affecting the function of the cannabinoid system is serving as a probe to demonstrate the involvement of cannabinoid and opioid transmitters on the formation of placebo effects.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adult
/ Affect
/ Biological and medical sciences
/ Coding
/ Female
/ Humans
/ Male
/ Medicine
/ Morphine
/ Mutation, Missense - genetics
/ Neurotransmitters. Neurotransmission. Receptors
/ Opioids
/ Pain
/ Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
/ Pharmacology. Drug treatments
/ Placebos
/ Positron-Emission Tomography
/ Receptors, Dopamine D2 - metabolism
/ Receptors, Dopamine D3 - metabolism
/ Receptors, Opioid, mu - metabolism
