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Impact of tumor size on survival of patients with resected pancreatic ductal adenocarcinoma: a systematic review and meta-analysis
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Impact of tumor size on survival of patients with resected pancreatic ductal adenocarcinoma: a systematic review and meta-analysis
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Impact of tumor size on survival of patients with resected pancreatic ductal adenocarcinoma: a systematic review and meta-analysis
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Journal Article
Impact of tumor size on survival of patients with resected pancreatic ductal adenocarcinoma: a systematic review and meta-analysis
2018
Overview
Background
The impact of tumor size on prognosis for surgically treated patients with pancreatic ductal adenocarcinoma (PDAC) remains controversial. A systematic review and meta-analysis was performed to evaluate this issue.
Methods
Relevant studies published from January 2000 to June 2017 were identified through EMBASE and PUBMED. Data were pooled for meta-analysis using Review Manager 5.3.
Results
Twenty eight observational studies involving a total of 23,945 patients were included. Tumors > 2 cm was associated with poor prognosis: the pooled hazard ratio (HR) estimate for overall survival was 1.52 (95% confidence interval [CI]: 1.41–1.64;
P
< 0.0001) by univariate analysis and 1.61 (95% CI: 1.35–1.91;
P
< 0.0001) by multivariate analysis; the pooled HR estimate for disease-free survival was 1.74 (95% CI: 1.46–2.07;
P
< 0.0001) by univariate analysis and 1.38 (95% CI: 1.12–1.68;
P
= 0.002) by multivariate analysis. When compared with patients with tumors ≤2 cm, those with the tumors > 2 cm had higher incidences of lymph node metastasis, poor tumor differentiation, lymph vessel invasion, vascular invasion, perineural invasion, and positive intraoperative peritoneal cytology.
Conclusion
These data demonstrate that PDAC size > 2 cm is an independent predictive factor for poor prognosis after surgical resection and associated with more aggressive tumor biology.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Biomedical and Life Sciences
/ Carcinoma, Pancreatic Ductal - pathology
/ Carcinoma, Pancreatic Ductal - surgery
/ Cytology
/ Health Promotion and Disease Prevention
/ Humans
/ Observational Studies as Topic
/ Oncology
/ Pancreas
/ Pancreatic ductal adenocarcinoma
/ Pancreatic Neoplasms - pathology
/ Pancreatic Neoplasms - surgery
/ Size
/ Studies
/ Surgery
/ Survival
/ Tumors
