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Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota
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Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota
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Journal Article
Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota
2015
Overview
Secretory IgA (SIgA) shapes the gut microbial composition. Pabst and colleagues show that the IgA-secreting plasma cell repertoire, once established, is remarkably resilient to changes in microbial populations that occur upon infection or antibiotic treatment.
Secretory immunoglobulin A (SIgA) shields the gut epithelium from luminal antigens and contributes to host-microbe symbiosis. However, how antibody responses are regulated to achieve sustained host-microbe interactions is unknown. We found that mice and humans exhibited longitudinal persistence of clonally related B cells in the IgA repertoire despite major changes in the microbiota during antibiotic treatment or infection. Memory B cells recirculated between inductive compartments and were clonally related to plasma cells in gut and mammary glands. Our findings suggest that continuous diversification of memory B cells constitutes a central process for establishing symbiotic host-microbe interactions and offer an explanation of how maternal antibodies are optimized throughout life to protect the newborn.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 64/60
/ Adaptation, Physiological - immunology
/ Animals
/ Anti-Bacterial Agents - pharmacology
/ Female
/ Gastrointestinal Tract - drug effects
/ Gastrointestinal Tract - immunology
/ Gastrointestinal Tract - microbiology
/ Host-Pathogen Interactions - drug effects
/ Host-Pathogen Interactions - immunology
/ Humans
/ Immunoglobulin A - immunology
/ Immunoglobulin A - metabolism
/ Immunoglobulin A, Secretory - immunology
/ Immunologic Memory - immunology
/ Mammary Glands, Animal - immunology
/ Mammary Glands, Animal - metabolism
/ Microbiota (Symbiotic organisms)
/ Mutation
