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Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain

by Zhang, Xueying , Henn, Fritz , Li, Yao , Manganas, Louis N , Hazel, Raphael D , Benveniste, Helene , Djurić, Petar M , Smith, S. David , Wagshul, Mark E , Enikolopov, Grigori , Maletić-Savatić, Mirjana

in Adolescent / Adult / Adult Stem Cells - chemistry / Adult Stem Cells - cytology / Algorithms / Animals / Biological and medical sciences / Biological markers / biomarkers / Biomarkers - analysis / Biomarkers - chemistry / Brain / Brain - cytology / Brain - embryology / Brain Chemistry / Cell Differentiation / Cellular differentiation / Chemical equilibrium / Child / Embryonic Stem Cells - chemistry / Embryonic Stem Cells - cytology / Fatty Acids - analysis / Fatty Acids - chemistry / Female / Fundamental and applied biological sciences. Psychology / General aspects. Models. Methods / Hippocampus / Hippocampus - chemistry / Hippocampus - cytology / Humans / image analysis / Magnetic Resonance Spectroscopy - methods / Male / Medical imaging / Mice / monitoring / Neural stem cells / Neurogenesis / Neurology / Neurons / Neurons - chemistry / Neurons - cytology / NMR / Nuclear magnetic resonance / nuclear magnetic resonance spectroscopy / Protons / Quantification / Rats / rodents / Signal Processing, Computer-Assisted / Spectroscopy / Spectrum analysis / Stem cells / Stem Cells - chemistry / Stem Cells - cytology / T lymphocytes / Vertebrates: nervous system and sense organs

2007

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Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain

2007

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2007

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Journal Article

Magnetic Resonance Spectroscopy Identifies Neural Progenitor Cells in the Live Human Brain

Zhang, Xueying,

Henn, Fritz,

Li, Yao,

Manganas, Louis N,

Hazel, Raphael D,

Benveniste, Helene,

Djurić, Petar M,

Smith, S. David,

Wagshul, Mark E,

Enikolopov, Grigori,

Maletić-Savatić, Mirjana

2007

Overview

The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentrations of NPCs in vivo, we developed a signal processing method that enabled the use of magnetic resonance spectroscopy for the analysis of the NPC biomarker in both the rodent brain and the hippocampus of live humans. Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Adolescent

/ Adult

/ Adult Stem Cells - chemistry

/ Adult Stem Cells - cytology

/ Algorithms

/ Animals

/ Biological and medical sciences