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Plasma cell differentiation requires the transcription factor XBP-1
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Journal Article
Plasma cell differentiation requires the transcription factor XBP-1
2001
Overview
Considerable progress has been made in identifying the transcription factors involved in the early specification of the B-lymphocyte lineage. However, little is known about factors that control the transition of mature activated B cells to antibody-secreting plasma cells. Here we report that the transcription factor XBP-1 is required for the generation of plasma cells. XBP-1 transcripts were rapidly upregulated
in vitro
by stimuli that induce plasma-cell differentiation, and were found at high levels in plasma cells from rheumatoid synovium. When introduced into B-lineage cells, XBP-1 initiated plasma-cell differentiation. Mouse lymphoid chimaeras deficient in XBP-1 possessed normal numbers of activated B lymphocytes that proliferated, secreted cytokines and formed normal germinal centres. However, they secreted very little immunoglobulin of any isotype and failed to control infection with the B-cell-dependent polyoma virus, because plasma cells were markedly absent. XBP-1 is the only transcription factor known to be selectively and specifically required for the terminal differentiation of B lymphocytes to plasma cells.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
/ Arthritis, Rheumatoid - immunology
/ Biological and medical sciences
/ Cell differentiation, maturation, development, hematopoiesis
/ Cells
/ Chimera
/ DNA-Binding Proteins - genetics
/ DNA-Binding Proteins - physiology
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humanities and Social Sciences
/ Mice
/ Molecular and cellular biology
/ Plasma
/ Proteins
/ Regulatory Factor X Transcription Factors
/ Science
