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Rosai-Dorfman-Destombes (RDD) disease presenting as palindromic rheumatism
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Journal Article
Rosai-Dorfman-Destombes (RDD) disease presenting as palindromic rheumatism
2021
Overview
Background
Rosai-Dorfman-Destombes (RDD) disease, is a rare proliferative and inflammatory disorder of non-Langerhans cell histiocytes.
Case presentation
We report a 35-year-old woman, who originally presented with recurrent episodes of lower extremity joint/bone pain and chronic nasal stuffiness and congestion. Her worsening nasal congestion was due to an obstructing nasal cavity lesion which was subsequently biopsied. Pathology was consistent with RDD.
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F-FDG PET images demonstrated intense uptake in the paranasal sinuses and a large pelvic lymph node. Focal osseous lesions with intense
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F-FDG uptake were also observed in the lower extremity, corresponding to areas of peri-articular pain. Rheumatologic work-up was consistent with palindromic rheumatism. She was diagnosed with immune-related disseminated RDD, presenting as palindromic rheumatism.
Conclusions
This is the first case of RDD presenting as palindromic rheumatism. RDD should be considered as a possible but rare diagnosis in young patients with sinus-related symptoms and lymphadenopathy. The disease can on rare occasions be disseminated and can also present as immune-related RDD, such as in this patient.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Adult
/ Arthritis, Rheumatoid - diagnostic imaging
/ Arthritis, Rheumatoid - etiology
/ Blocking
/ Disease
/ Female
/ Histiocytosis, Sinus - complications
/ Histiocytosis, Sinus - diagnostic imaging
/ Histiocytosis, Sinus - pathology
/ Humans
/ Imaging
/ Lesions
/ Lupus
/ Lymphadenopathy - diagnostic imaging
/ Lymphoma
/ Medicine
/ Nose
/ Nose Diseases - complications
/ Nose Diseases - diagnostic imaging
/ Pain
/ Paranasal Sinuses - diagnostic imaging
/ Pelvic Bones - diagnostic imaging
/ Plasma
/ Positron emission tomography
/ Rosai-Dorfman-Destombes disease
/ Sinus
/ Sinus histiocytosis with massive lymphadenopathy
/ Sinuses
/ Tumors
