Journal Article

Lower peripheral blood CD14+ monocyte frequency and higher CD34+ progenitor cell frequency are associated with HBV vaccine induced response in HIV infected individuals

Umbleja, T., Peters, M.G., Medvik, K., Lederman, M.M., Anthony, D.D., Koziel, M.J., Overton, E.T., Kang, M., Aberg, J.A.

2011

Overview

We evaluated immunologic predictors of response to HBV vaccine administered in the presence or absence of GM-CSF in HIV infected individuals. We measured peripheral blood hematopoietic progenitor, monocyte and myeloid-derived suppressor cell (MDSC) frequencies, and expression of GMCSF receptor on monocytes and MDSCs, at baseline and 4weeks after immunization in relation to antibody response. We observed higher baseline progenitor and lower monocyte frequencies among week 16 antibody responders. Week 4 decline in MDSC frequency was associated with week 16 antibody response, while administration of GM-CSF was associated with preservation of these cells. No significant differences in GM-CSF receptor expression were observed in the presence vs. absence of GM-CSF. These findings are consistent with a positive role of progenitor cells and a potential negative role of monocytes in vaccine response. Additionally, GM-CSF augmented the preservation of peripheral blood MDSC, which may contribute to the lack of improved vaccine responses.

• Publisher: Elsevier Ltd,Elsevier,Elsevier Limited
• Subject: Acquired immune deficiency syndrome / AIDS / Allergy and Immunology / Antibody Formation / Antibody response / Antigen-Presenting Cells - immunology / Antigens / Antigens, CD34 - immunology / Applied microbiology / Biological and medical sciences / CD34 antigen / CD4-Positive T-Lymphocytes - immunology / CD8-Positive T-Lymphocytes / Cellular immunity / Clinical trials / Female / Fundamental and applied biological sciences. Psychology / Granulocyte-macrophage colony-stimulating factor / Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage / Granulocyte-Macrophage Colony-Stimulating Factor - immunology / Hematopoietic Stem Cells - immunology / Hemopoiesis / Hepatitis B / Hepatitis B Antibodies - blood / Hepatitis B Vaccines - adverse effects / Hepatitis B Vaccines - immunology / Hepatitis B virus / HIV / HIV - immunology / HIV infections / HIV Infections - immunology / Human / Human immunodeficiency virus / Human viral diseases / Humans / Immunization / Infections / Infectious diseases / Lipopolysaccharide Receptors - immunology / Lymphocytes / Male / Medical sciences / Microbiology / Middle Aged / Miscellaneous / Monocyte / Monocytes / Monocytes - immunology / Mortality / Peripheral blood / Pilot Projects / Population / Preservation / Progenitor cell / Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - immunology / Statistical methods / Stem cells / Studies / Suppressor cells / Vaccine / Vaccines / Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) / Viral diseases / Viral diseases of the lymphoid tissue and the blood. Aids / Virology