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Functions of FGF signalling from the apical ectodermal ridge in limb development
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Functions of FGF signalling from the apical ectodermal ridge in limb development
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Journal Article
Functions of FGF signalling from the apical ectodermal ridge in limb development
2002
Overview
To determine the role of fibroblast growth factor (FGF) signalling from the apical ectodermal ridge (AER), we inactivated
Fgf4
and
Fgf8
in AER cells or their precursors at different stages of mouse limb development. We show that FGF4 and FGF8 regulate cell number in the nascent limb bud and are required for survival of cells located far from the AER. On the basis of the skeletal phenotypes observed, we conclude that these functions are essential to ensure that sufficient progenitor cells are available to form the normal complement of skeletal elements, and perhaps other limb tissues. In the complete absence of both FGF4 and FGF8 activities, limb development fails. We present a model to explain how the mutant phenotypes arise from FGF-mediated effects on limb bud size and cell survival.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
/ Animals
/ Biological and medical sciences
/ Cells
/ Embryology: invertebrates and vertebrates. Teratology
/ Female
/ Fibroblast Growth Factors - genetics
/ Fibroblast Growth Factors - metabolism
/ Fundamental and applied biological sciences. Psychology
/ Gene Expression Regulation, Developmental
/ Humanities and Social Sciences
/ Male
/ Mice
/ Muscle, Skeletal - embryology
/ Muscle, Skeletal - metabolism
/ Organogenesis. Physiological fonctions
/ Rodents
/ Science
