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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
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Journal Article
The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
2010
Overview
Recent evidence suggests that mutations in
LRRK2
are linked to Parkinson's disease. In this Progress article, Mark Cookson discusses how these mutations might affect LRRK2 function and its interactions with other proteins that have been implicated in Parkinson's disease, specifically α-synuclein and tau.
Parkinson's disease, like many common age-related conditions, is now recognized to have a substantial genetic component. Here, I discuss how mutations in a large complex gene — leucine-rich repeat kinase 2 (
LRRK2
) — affect protein function, and I review recent evidence that
LRRK2
mutations affect pathways that involve other proteins that have been implicated in Parkinson's disease, specifically α-synuclein and tau. These concepts can be used to understand disease processes and to develop therapeutic opportunities for the treatment of Parkinson's disease.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ alpha-Synuclein - metabolism
/ Animal Genetics and Genomics
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Central Nervous System - metabolism
/ Central Nervous System - pathology
/ Dopamine
/ Fundamental and applied biological sciences. Psychology
/ General aspects. Models. Methods
/ Genes
/ Genetic Predisposition to Disease - genetics
/ Humans
/ Kinases
/ Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
/ Mutation
/ Parkinson Disease - genetics
/ Parkinson Disease - metabolism
/ Parkinson Disease - pathology
/ progress
/ Protein Serine-Threonine Kinases - genetics
/ Protein Serine-Threonine Kinases - metabolism
/ Proteins
