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Computer identification of Notch3 in the neurogenic progenitor cells of mammalian early optic vesicles
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Computer identification of Notch3 in the neurogenic progenitor cells of mammalian early optic vesicles
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Computer identification of Notch3 in the neurogenic progenitor cells of mammalian early optic vesicles
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Journal Article
Computer identification of Notch3 in the neurogenic progenitor cells of mammalian early optic vesicles
2025
Overview
Objective
The developing mammalian retina initially contains undifferentiated cells, providing a model for investigating the mechanisms of differentiation. Notch signaling, mediated by four Notch receptors (
Notch 1–4
) in mammals, has been studied in the differentiation of neural progenitor cells. Among the four Notch receptors, the frequency, rather than the peak level, of
Notch1
-mediated signaling has been suggested to promote the activation of neural progenitor cells. In contrast to
Notch1
, the involvement of
Notch3
in this process is poorly documented, although
Notch3
is known for its role in vascular integrity.
Results
By re-analyzing publicly available single-cell RNA-seq data from one mouse retinal dataset, two human retinal organoid datasets and two human embryonic retinal datasets, we found that, along with
Notch1
,
Notch3
is expressed in neural progenitor cells in the retina. In addition, the results of the co-expression profile analyses varied among the datasets, leaving uncertainty regarding the regulatory mechanisms of
Notch1
and
Notch3
. Our findings shed light on
Notch3
in neurogenic progenitor cells of the developing mammalian retina. Since
Notch3
has been suggested to cause ligand-independent signaling,
Notch3
expression might antagonize
Notch1
-mediated signaling oscillations, maintaining the quiescent state of neurogenic progenitor cells.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
