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Antiepileptic Medications in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
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Antiepileptic Medications in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
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Journal Article
Antiepileptic Medications in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
2014
Overview
Electroencephalogram-recorded epileptiform activity is common in children with autism spectrum disorder (ASD), even without clinical seizures. A systematic literature search identified 7 randomized, placebo-controlled trials of antiepileptic drugs (AEDs) in ASD (total n = 171), including three of valproate, and one each of lamotrigine, levetiracetam, and topiramate. Meta-analysis revealed no significant difference between medication and placebo in four studies targeting irritability/agitation and three studies investigating global improvement, although limitations include lack of power and different medications with diverse actions. Across all seven studies, there was no significant difference in discontinuation rate between two groups. AEDs do not appear to have a large effect size to treat behavioral symptoms in ASD, but further research is needed, particularly in the subgroup of patients with epileptiform abnormalities.
Publisher
Springer Science and Business Media LLC,Springer US,Springer,Springer Nature B.V
Subject
/ Anticonvulsants - therapeutic use
/ Autism
/ Behavioral Science and Psychology
/ Biological and medical sciences
/ Child
/ Child Development Disorders, Pervasive
/ Child Development Disorders, Pervasive - drug therapy
/ Child Development Disorders, Pervasive - psychology
/ Children
/ Complications and side effects
/ Drugs
/ Epilepsy
/ Fructose
/ Fructose - analogs & derivatives
/ Humans
/ Irritable Mood - drug effects
/ Overt Aggression Scale (Yudofsky)
/ Patients
/ Pervasive Developmental Disorders
/ Pharmacology. Drug treatments
/ Piracetam - analogs & derivatives
/ Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
/ Psychology. Psychoanalysis. Psychiatry
/ Seizures
/ Symptoms
