Journal Article

High seroconversion rate to Rift Valley fever virus in cattle and goats in far northern KwaZulu-Natal, South Africa, in the absence of reported outbreaks

van den Bergh, Carien, Venter, Estelle H., Thompson, Peter N., Swanepoel, Robert

2019

Overview

BACKGROUND : Rift Valley fever (RVF) is a mosquito-borne zoonotic disease characterized in South Africa by large epidemics amongst ruminant livestock at very long, irregular intervals, mainly in the central interior. However, the presence and patterns of occurrence of the virus in the eastern parts of the country are poorly known. This study aimed to detect the presence of RVF virus (RVFV) in cattle and goats in far northern KwaZulu-Natal province and to estimate the prevalence of antibodies to the virus and the incidence rate of seroconversion. METHODOLOGY : Cross-sectional studies were performed in communally farmed cattle (n = 423) and goats (n = 104), followed by longitudinal follow-up of seronegative livestock (n = 253) 14 times over 24 months, representing 160.3 animal-years at risk. Exposure to RVFV was assessed using an IgG sandwich ELISA and a serum neutralization test (SNT) and seroconversion was assessed using SNT. Incidence density was estimated and compared using multivariable Poisson models and hazard of seroconversion was estimated over time. PRINCIPAL FINDINGS : Initial overall seroprevalence was 34.0% (95%CI: 29.5–38.8%) in cattle and 31.7% (95%CI: 22.9–41.6%) in goats, varying by locality from 18–54%. Seroconversions to RVFV based on SNT were detected throughout the year, with the incidence rate peaking during the high rainfall months of January to March, and differed considerably between years. Overall seroconversion rate in cattle was 0.59 per animal-year (95% CI: 0.46–0.75) and in goats it was 0.41 per animal-year (95% CI: 0.25–0.64), varying significantly over short distances. CONCLUSIONS/SIGNIFICANCE : The high seroprevalence in all age groups and evidence of year-round viral circulation provide evidence for a hyperendemic situation in the study area. This is the first study to directly estimate infection rate of RVFV in livestock in an endemic area in the absence of reported outbreaks and provides the basis for further investigation of factors affecting viral circulation and mechanisms for virus survival during interepidemic periods.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Age groups / Animals / Antibodies / Antibodies, Viral - blood / Aquatic insects / Beef cattle / Biology and life sciences / Bovidae / Care and treatment / Cattle / Cattle Diseases - blood / Cattle Diseases - epidemiology / Cattle Diseases - virology / Cattle industry / Coccidioidomycosis / Cross-Sectional Studies / Disease / Disease Outbreaks / Earth Sciences / ELISA / Enzyme-linked immunosorbent assay / Epidemics / Epidemiology / Female / Fever / Funding / Goat Diseases - blood / Goat Diseases - epidemiology / Goat Diseases - virology / Goats / Health aspects / Humans / Immunoglobulin G / Immunoglobulin G - blood / Immunoglobulins / Incidence / Livestock / Male / Medical research / Medicine and health sciences / Mosquitoes / Neutralization / Outbreaks / People and places / Prevalence studies (Epidemiology) / Rain / Rainfall / Rift Valley fever / Rift Valley Fever - blood / Rift Valley Fever - epidemiology / Rift Valley Fever - virology / Rift Valley fever virus - genetics / Rift Valley fever virus - immunology / Rift Valley fever virus - isolation & purification / Risk factors / Seroconversion / Seroepidemiologic Studies / Serum / South Africa - epidemiology / Survival / Tropical diseases / Vector-borne diseases / Viral diseases / Viruses / Zoonoses