Journal Article

Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8$^{-/-}$ Mice

Mak, Tak-Wah, Fung-Leung, Wai-Ping, Koh, Dow-Rhoon, Ho, Alexandra, Gray, Dawn, Acha-Orbea, Hans

1992

Overview

Mice lacking in CD8 were generated from homologous recombination in embryonal stem cells at the CD8 locus and bred with the experimental allergic encephalomyelitis (EAE)-susceptible PL/J H-2$^u$ through four backcross generations to investigate the role of CD8$^+$ T cells in this model of multiple sclerosis. The disease onset and susceptibility were similar to those of wild-type mice. However, the mutant mice had a milder acute EAE, reflected by fewer deaths, but more chronic EAE, reflected by a higher frequency of relapse. This suggests that CD8$^+$ T lymphocytes may participate as both effectors and regulators in this animal model.

• Publisher: American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science
• Subject: Anatomy / Animals / Antibodies / Antigens / Attrition (Research Studies) / Autoimmune diseases / Body Weight / CD8 Antigens - genetics / CD8 Antigens - metabolism / CD8 lymphocytes / Cellular biology / Crosses, Genetic / Death / Disease course / Disease models / Disease Models, Animal / Disease resistance / DNA Replication / Encephalomyelitis, Autoimmune, Experimental - immunology / Encephalomyelitis, Autoimmune, Experimental - physiopathology / Feedback (Response) / Female / Interleukin-2 - biosynthesis / Male / Medical research / Mice / Mice, Inbred Strains / Mice, Mutant Strains / Mortality / Multiple sclerosis / Multiple Sclerosis - immunology / Multiple Sclerosis - physiopathology / Nervous system diseases / Physiological aspects / Reference Values / Relapse / Rodents / T cells / T lymphocytes / T-Lymphocytes - immunology / Thymidine - metabolism