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Protective effects of Lactobacillus plantarum strain against protein malnutrition-induced muscle atrophy and bone loss in juvenile mice
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Protective effects of Lactobacillus plantarum strain against protein malnutrition-induced muscle atrophy and bone loss in juvenile mice
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Journal Article
Protective effects of Lactobacillus plantarum strain against protein malnutrition-induced muscle atrophy and bone loss in juvenile mice
2025
Overview
Early-life malnutrition adversely affects nearly all organ systems, resulting in multiple physiological adaptations, including growth restriction and muscle and bone loss. Although there is growing evidence that probiotics effectively improve systemic growth under malnourished conditions in different animal models, our knowledge of the beneficial effects of probiotics on various organs is limited. Here, we show that Lactobacillus plantarum strain WJL (Lp WJL ) can mitigate skeletal muscle and bone loss in protein-malnourished juvenile mice. Mice on prenatal day 21 were fed a protein-malnourished (P-MAL) diet with or without Lp WJL supplementation for six weeks. Compared to mice on the P-MAL diet alone, Lp WJL supplementation significantly increased muscle mass and size, resulting in enhanced muscle strength and endurance capacity. Furthermore, Lp WJL supplementation induced the expression of the key growth factor IGF-1 while decreasing muscle atrophy markers such as Atrogin-1 and MuRF-1, indicating potential mechanisms by which protein malnutrition-induced muscle wasting is counteracted. Additionally, Lp WJL supplementation alleviated the reduction in cortical bone thickness and the deterioration of trabecular bone microstructure in the femur. Taken together, these results indicate that Lp WJL can protect against skeletal muscle atrophy and compromised bone microarchitecture caused by protein malnutrition, providing novel insights into the potential therapeutic applications of probiotics for treating malnutrition-related disorders.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Atrophy
/ Complications and side effects
/ Diarrhea
/ Diet
/ Female
/ Femur
/ Insulin-like growth factor I
/ Insulin-Like Growth Factor I - metabolism
/ Lactobacillus plantarum - physiology
/ Male
/ Medicine and Health Sciences
/ Mice
/ Muscle Proteins - metabolism
/ Muscle, Skeletal - metabolism
/ Muscle, Skeletal - pathology
/ Muscular Atrophy - pathology
/ Muscular Atrophy - prevention & control
/ Probiotics - therapeutic use
/ Proteins
/ Research and Analysis Methods
/ Running
/ Testing
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