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Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior
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Journal Article
Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior
2015
Overview
Using optogenetic manipulations and bioluminescence imaging of suprachiasmatic nucleus (SCN) firing rate, this study examines the interaction between molecular, electrical and behavioral circadian rhythms in mice. The study shows that alteration of clock neuron firing can reset molecular and behavioral circadian rhythms, and this effect required neuronal network interaction within the SCN. Thus, clock neuron spiking is fundamental to circadian pacemaking as both an input to and output of the neuronal network responsible for circadian behavior.
To examine the interaction between molecular, electrical and behavioral circadian rhythms, we combined optogenetic manipulation of suprachiasmatic nucleus (SCN) firing rate with bioluminescence imaging and locomotor activity monitoring. Manipulating firing rate reset circadian rhythms both
ex vivo
and
in vivo
, and this resetting required spikes and network communication. This suggests that SCN firing rate is fundamental to circadian pacemaking as both an input to and output of the molecular clockworks.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 14/19
/ 14/5
/ 64/60
/ 9/74
/ Action Potentials - drug effects
/ Action Potentials - physiology
/ Animal Genetics and Genomics
/ Animals
/ Behavior
/ Circadian Rhythm - physiology
/ Luminescent Proteins - genetics
/ Luminescent Proteins - metabolism
/ Mice
/ Neurons
/ Period Circadian Proteins - genetics
/ Period Circadian Proteins - metabolism
/ Receptors, Dopamine D1 - genetics
/ Receptors, Dopamine D1 - metabolism
/ Sodium Channel Blockers - pharmacology
