Journal Article

Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses

Department of Biology, Division of Biochemistry ; Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg (FAU), Shirasu, Ken, 6. Department of Postharvest Science of Fresh Produce, Agricultural Research Organizati ; Agricultural Research Organization, Law, Audrey D, Cologne Center for Genomics ; Universität zu Köln = University of Cologne, Department of Plant Pathology ; University of Florida [Gainesville] (UF), Sikhakolli, Usha R, Lee, Yong-Hwan, Altmüller, Janine, Henrissat, Bernard, Rounsley, Steve, Reinhardt, Richard, Rollings, Jeffrey A, Laboratory of Plant Pathology, Graduate School of Agriculture ; Kyoto University, Schulze-Lefert, Paul, Broad Institute [Cambridge] ; Harvard University-Massachusetts Institute of Technology (MIT), Department of Plant Biology ; Michigan State University [East Lansing] ; Michigan State University System-Michigan State University System, Farman, Mark A, Epstein, Lynn, Alvarado-Balderrama, Lucia, Department of Plant Pathology ; University of California (UC), Vai

2012

Overview

Colletotrichum species are fungal pathogens that devastate crop plants worldwide. Host infection involves the differentiation of specialized cell types that are associated with penetration, growth inside living host cells (biotrophy) and tissue destruction (necrotrophy). We report here genome and transcriptome analyses of Colletotrichum higginsianum infecting Arabidopsis thaliana and Colletotrichum graminicola infecting maize. Comparative genomics showed that both fungi have large sets of pathogenicity-related genes, but families of genes encoding secreted effectors, pectin-degrading enzymes, secondary metabolism enzymes, transporters and peptidases are expanded in C. higginsianum. Genome-wide expression profiling revealed that these genes are transcribed in successive waves that are linked to pathogenic transitions: effectors and secondary metabolism enzymes are induced before penetration and during biotrophy, whereas most hydrolases and transporters are upregulated later, at the switch to necrotrophy. Our findings show that preinvasion perception of plant-derived signals substantially reprograms fungal gene expression and indicate previously unknown functions for particular fungal cell types.

• Publisher: Nature Publishing Group,CCSD,Nature Publishing Group US
• Subject: 631/208/191/2018 / 631/208/212/2019 / 631/208/2491 / Agriculture / Animal Genetics and Genomics / Arabidopsis - microbiology / Arabidopsis thaliana / Biological and medical sciences / Biomedicine / Cancer Research / Cellulase / Chromosomes / Cluster Analysis / Colleges & universities / Colletotrichum / Colletotrichum - genetics / Colletotrichum - growth & development / Colletotrichum - pathogenicity / Colletotrichum graminicola / Fundamental and applied biological sciences. Psychology / Fungi, Phytopathogenic / Gene Expression Profiling / Gene Expression Regulation, Developmental / Gene Expression Regulation, Fungal / Gene Function / Genetic aspects / Genetics / Genetics of eukaryotes. Biological and molecular evolution / Genome, Fungal - genetics / Genomes / Genomics / Grants / Grasses / Host-Pathogen Interactions - genetics / Human Genetics / Infections / letter / Life Sciences / Mitosporic Fungi - genetics / Mitosporic Fungi - growth & development / Mitosporic Fungi - pathogenicity / Models, Biological / Molecular and cellular biology / Molecular genetics / Phenols / Phylogeny / Plant Diseases - genetics / Plant Diseases - microbiology / Proteins / Ribosomal DNA / Sequence Analysis, DNA / Transcription. Transcription factor. Splicing. Rna processing / Transcriptome - genetics / Zea mays
• ISBN: 0003084912000