Journal Article

Antioxidant Action of Mangrove Polyphenols against Gastric Damage Induced by Absolute Ethanol and Ischemia-Reperfusion in the Rat

Toma, Walber, Almeida, Ana Cristina Alves, Salvador, Marcos José, de-Faria, Felipe Meira, da Silva, Marcelo Aparecido, Eberlin, Marcos Nogueira, Vilegas, Wagner, Abdelnur, Patrícia Verardi, Souza-Brito, Alba Regina Monteiro, Luiz-Ferreira, Anderson, Takayama, Christiane, Dunder, Ricardo José

2012

Overview

Rhizophora mangle, the red mangrove, has long been known as a traditional medicine. Its bark has been used as astringent, antiseptic, hemostatic, with antifungic and antiulcerogenic properties. In this paper, we aimed to evaluate the antioxidant properties of a buthanolic fraction of the R. mangle bark extract (RM) against experimental gastric ulcer in rats. Unib-Wh rats received pretreatment of R. mangle after the induction of gastric injury with absolute ethanol and ischemia-reperfusion. Gastric tissues from both methods were prepared to the enzymatic assays, the levels of sulfhydril compounds (GSH), lipid peroxides (LPO), and the activities of glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and myeloperoxidase (MPO) were measured. The RM protected the gastric mucosa in both methods used, ethanol-induced gastric ulcer and ischemia-reperfusion, probably, by modulating the activities of the enzymes SOD, GPx, and GR and increasing or maintaining the levels of GSH; in adittion, LPO levels were reduced. The results suggest that the RM antioxidant activity leads to tissue protection; thus one of the antiulcer mechanisms present on the pharmacological effects of R. mangle is the antioxidant property.

• Publisher: Hindawi Puplishing Corporation,The Scientific World Journal,John Wiley & Sons, Inc,Hindawi Limited,Wiley
• Subject: Alcohol / Alcohol, Denatured / Animals / Antioxidants / Antioxidants - chemistry / Antioxidants - therapeutic use / Aquatic plants / Bark / Care and treatment / Catalase / Ethanol / Ethanol - toxicity / Gastric mucosa / Glutathione / Glutathione - metabolism / Glutathione peroxidase / Glutathione Peroxidase - metabolism / Glutathione reductase / Health aspects / Ischemia / Lipid Peroxidation - drug effects / Lipid Peroxides - metabolism / Male / Mangrove plants / Peroxidase / Peroxidase - metabolism / Peroxides / Pharmacology / Plant Bark - chemistry / Plant extracts / Plant Extracts - chemistry / Plant Extracts - therapeutic use / Polyphenols / Pretreatment / Rats / Reperfusion / Reperfusion injury / Reperfusion Injury - drug therapy / Rhizophora mangle / Rhizophoraceae - chemistry / Stomach diseases / Stomach Ulcer - chemically induced / Stomach Ulcer - drug therapy / Superoxide dismutase / Superoxide Dismutase - metabolism